Cell Contact & Adhesion Gordon Research Conference

电池接触

• 批准号: 7799939
• 负责人: PIERRE D MCCREA
• 金额: $ 0.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-06 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7799939
• 关键词: Address; Adhesions; Adhesives; Area; Basic Science; Biological Models; Bulla; Cell Line; Cell Polarity; Cell-Cell Adhesion; Cells; Collaborations; Communication; Development; Discipline; Disease; Environment; Fostering; Future; Generations; Genetic Crossing Over; Goals; Human; Individual; International; Invertebrates; Maintenance; Malignant Neoplasms; Molecular; Neoplasm Metastasis; New Hampshire; Outcome; Pathology; Physiology; Plant Roots; Process; Research; Research Personnel; Resort; Signal Pathway; Site; Sum; System; Tissues; Trust; United States National Institutes of Health; Woman; cancer initiation; grasp; human disease; interest; meetings; microbial; pathogen; public health relevance; skin disorder; symposium

DESCRIPTION (provided by applicant): We request partial support for three (3) international meetings on "Cell Contact & Adhesion", which will be held in 2009 (June 28 - July 3) at the Waterville Valley Resort (New Hampshire USA), and again in 2011 & 2013 - likely alternating between the Waterville Valley and Il Ciocco (Barga IT) sites. The larger goal and significance is to enhance our basic understanding of cell- cell adhesion systems at the molecular level, for example, how the molecules involved form physical adhesive contacts and how they contribute to signaling pathways allowing communication between cells. These concerns are central to obtaining a grasp of both normal development and multiple pathologies where aberrations in contact physiology are contributory. Human disease conditions of direct relevance include the progression of cancer from initiation through metastasis, host-pathogen interactions and blistering skin diseases. Nine (9) sessions are outlined, which together address the most exciting advances or areas of opportunity in a variety of cell-cell adhesion contexts - such as adherens, gap, tight and desmosomal junctions (as well as others). Using cell-line and diverse vertebrate and invertebrate model systems, a particular emphasis for the 2009 conference will be upon the generation and maintenance of cell polarity, as well as the execution of morphogenic processes. Such scientific interests relate intimately with an additional central session that will explicitly address cancer. Our specific aims in 2009 include the assembly 44 gifted speakers/ investigators and 9 session chairs. In conjunction with the Chair and Vice-Chair, such individuals will: provide the latest views and unpublished experimental evidence available in their research areas; facilitate the active discussion and debate of issues at the forefront of the cell-cell adhesion field and its cross-over disciplines; foster an environment where researchers can develop meaningful professional relationships and the trust needed to promote future collaborations; assist the active involvement of women and under-represented groups; encourage the significant participation of individuals from around the globe; and importantly, facilitate the mixing of postdoctoral and graduate trainees with more senior investigators. In sum, over the course of three (3) conferences that will span five years, the NIH support we seek will be instrumental to an important and dynamic field with deep roots in both basic science and the understanding of human disease. Public Health Relevance: The Cell Contact & Adhesion Gordon Research Conference will advance research facilitating better outcomes for humans afflicted by diseases such as cancer, microbial invasion and blistering skin diseases. In these and additional pathologies, contact and communication that would normally take place between neighboring cells becomes altered and leads to the disruption of both cell and tissue functions, for example, as occurs during cancer metastasis. By providing both young and senior investigators an opportunity to share their latest results first-hand while developing trust to facilitate future collaborations, the proposed conference provides a valuable and proven opportunity to spur needed biomedical advances.

描述（由申请人提供）：我们要求针对“牢房联系与粘附”的三（3）次国际会议进行部分支持，该会议将于2009年（6月28日至7月3日）在Waterville Valley Resort（美国新罕布什尔州美国）举行，并在2011年和2013年再次举行 - 很可能在Waterville Valley和Illy Ciocco（Barga（Barga IT）站点之间交替。更大的目标和意义是增强我们对分子水平细胞细胞粘附系统的基本理解，例如，涉及的分子如何形成物理粘合剂接触以及它们如何对允许细胞之间通信的信号通路有贡献。这些问题对于获得正常发育的掌握和接触生理的畸变是有助于的多种病理的核心。人类疾病的直接相关条件包括癌症从开始到转移，宿主 - 病原体相互作用和发泡皮肤疾病的发展。 概述了九（9）次会议，共同解决了各种细胞粘附环境中最令人兴奋的进步或机会领域，例如粘附，缝隙，紧密和脱骨接头（以及其他）。使用细胞线和多样化的脊椎动物和无脊椎动物模型系统，2009年会议的特别强调将是细胞极性的产生和维持以及形态发生过程的执行。这种科学利益与将明确解决癌症的额外中央会议密切相关。 我们在2009年的具体目标包括44个有天赋的演讲者/调查人员和9张会议椅。与主席和副主席一起，此类人将：提供最新的观点和未发表的实验证据；促进在细胞粘附场及其跨界学科最前沿问题的积极讨论和辩论；培养研究人员可以建立有意义的专业关系以及促进未来合作所需的信任的环境；协助妇女和代表人数不足的群体的积极参与；鼓励全球个人的大量参与；重要的是，促进博士后和研究生学员与更多高级调查员的混合。总而言之，在将跨越五年的三（3）个会议的过程中，我们寻求的NIH支持将对一个重要而动态的领域发挥作用，在基础科学和对人类疾病的理解中都具有深厚的根源。 公共卫生相关性：细胞接触和粘附研究会议将进步研究，以促进因癌症，微生物侵袭和暴力皮肤疾病等疾病折磨的人类的更好结果。在这些及其他病理中，通常在相邻细胞之间发生的接触和通信会发生变化，并导致细胞和组织功能的破坏，例如，如癌症转移期间发生的那样。通过为年轻和高级调查员提供机会，在发展信任以促进未来的合作的同时，可以直接分享他们的最新成果，拟议的会议为刺激需要的生物医学进步提供了宝贵而可靠的机会。