A Mediterranean Diet in for Colon Cancer Prevention

地中海饮食有助于预防结肠癌

基本信息

批准号：
8004091
负责人：
Zora Djuric
金额：
$ 28.78万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-01 至 2012-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8004091
关键词：
Acids Adherence American Animals Anti-Inflammatory Agents Anti-inflammatory Biological Markers Biopsy Blood Blood specimen Canned Foods Carotenoids Cells Chemopreventive Agent Colon Carcinoma Colorectal Colorectal Cancer Computer-Assisted Image Analysis Conflict (Psychology)Data Detection Diet Dietary Fats Dietary Intervention Dietary Practices Dietary intake Dinoprostone Disease Eating Eicosanoid Production Eicosanoids Epidemiology Epithelial Epithelial Cell Proliferation Epithelial Cells Experimental Models Fat red 7B stain Fatty Acids Fiber Flexible fiberoptic sigmoidoscopy Food Health Healthy People 2010 Human Hydroxyeicosatetraenoic Acids Inflammation Inflammation Mediators Intake Intervention Label Leukotriene B4 Leukotrienes Lipoxygenase Liquid substance Meat Mediator of activation protein Mediterranean Diet Methods Milk Monounsaturated Fatty Acids Mucous Membrane Nuclear Nutrient Olives - dietary Participant Persons Pharmacologic Substance Phytochemical Plants Polyunsaturated Fatty Acids Potato Prevention approach Preventive Process Prostaglandin-Endoperoxide Synthase Prostaglandins Protocols documentation Randomized Recruitment Activity Relative (related person)Research Personnel Risk Role Serum Supplementation Testing Tissues arm base beef cancer prevention cancer risk carcinogenesis colorectal cancer prevention design eicosanoid metabolism fruits and vegetables improved monounsaturated fat morphometry novel polyunsaturated fat pressure programs prospective prostaglandin E3 stem tumorigenesis

项目摘要

DESCRIPTION (provided by applicant): A Mediterranean Diet for Colon Cancer Prevention: Epidemiological and animal studies indicate that the major components of the traditional Cretan-Mediterranean diet have great promise for the prevention of colorectal cancer while improving overall health. Relative to the American diet, the Mediterranean diet is lower in n-6 fatty acids, polyunsaturated fats, and red meat while intakes of plant-based foods and monounsaturated fats are higher. The hypothesis behind this proposal is that adherence to a Mediterranean type of diet will result in a decrease in n-6 fatty acids and increased n-3 and n-9 fatty acids in human colonic mucosa. This, together with other aspects of the diet such as increased intakes of phytochemicals in fruits and vegetables, is expected to modulate eicosanoid metabolism in normal colorectal mucosa to its anticarcinogenic state resulting in lower colonic proliferation. We will recruit 120 study participants who are at increased risk of colorectal cancer. Subjects will be randomized to a modified Mediterranean diet or a Healthy People 2010 diet for 6 months. The Mediterranean diet will be designed to decrease polyunsaturated fat intake and to increase intakes of monounsaturated fats, fruits and vegetables. These dietary changes are expected to not only decrease pro-inflammatory mediators and increase anti-inflammatory mediators, but to also change the types of eicosanoids that are produced from cyclooxygenases and lipoxygenases. Our pilot testing of this novel exchange list diet indicates that subjects can make very large dietary changes. Dietary intake data, blood samples and biopsies of normal mucosa from flexible sigmoidoscopy will be analyzed before and after intervention, and changes from baseline will be compared in the 2 diet arms. The specific endpoints are fatty acids and carotenoids in blood and mucosa, the types and levels of inflammatory mediators in the mucosa, and proliferation in the mucosa. We expect that the Healthy People 2010 diet will result in minimal changes relative to the Mediterranean diet. Increasing our understanding of the effects of dietary changes on human mucosa is fundamental to evaluating the potential of diet in colorectal cancer prevention. Such data would also validate the use of these biomarkers as screen for other dietary and/or pharmaceutical-based interventions aimed at slowing or reversing carcinogenesis. If beneficial effects can be demonstrated in mucosal biomarkers of colorectal cancer risk (prostaglandin E2, other eicosanoids, proliferation), such data may be used to justify a larger, prospective intervention with disease endpoints and more detailed dietary studies.

描述（由申请人提供）：预防结肠癌的地中海饮食：流行病学和动物研究表明，传统克里特岛-地中海饮食的主要成分对于预防结直肠癌同时改善整体健康有很大希望。相对于美国饮食，地中海饮食的 n-6 脂肪酸、多不饱和脂肪和红肉含量较低，而植物性食物和单不饱和脂肪的摄入量较高。该提议背后的假设是，坚持地中海式饮食将导致人类结肠粘膜中 n-6 脂肪酸减少，n-3 和 n-9 脂肪酸增加。这与饮食的其他方面（例如增加水果和蔬菜中植物化学物质的摄入量）一起，预计可以将正常结直肠粘膜中的类二十烷酸代谢调节至其抗癌状态，从而降低结肠增殖。我们将招募 120 名罹患结直肠癌风险较高的研究参与者。受试者将被随机分配接受改良地中海饮食或 Healthy People 2010 饮食，为期 6 个月。地中海饮食旨在减少多不饱和脂肪的摄入量并增加单不饱和脂肪、水果和蔬菜的摄入量。这些饮食变化预计不仅会减少促炎介质并增加抗炎介质，还会改变由环氧合酶和脂氧合酶产生的类二十烷酸的类型。我们对这种新颖的交换清单饮食的初步测试表明，受试者可以做出非常大的饮食改变。将在干预前后分析饮食摄入数据、血液样本和柔性乙状结肠镜检查的正常粘膜活检，并比较两个饮食组相对于基线的变化。具体终点是血液和粘膜中的脂肪酸和类胡萝卜素、粘膜中炎症介质的类型和水平以及粘膜中的增殖。我们预计 2010 年健康人饮食相对于地中海饮食将产生最小的变化。增加我们对饮食变化对人类粘膜影响的了解对于评估饮食在结直肠癌预防中的潜力至关重要。这些数据还将验证这些生物标志物作为其他旨在减缓或逆转致癌作用的基于饮食和/或药物的干预措施的筛选的用途。如果可以在结直肠癌风险的粘膜生物标志物（前列腺素 E2、其他类二十烷酸、增殖）中证明有益效果，则此类数据可用于证明对疾病终点和更详细的饮食研究进行更大规模、前瞻性干预的合理性。