WEIGHT LOSS IN OBESE BREAST CANCER SURVIVORS

肥胖乳腺癌幸存者的体重减轻

• 批准号: 6287640
• 负责人: Zora Djuric
• 金额: $ 7.45万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-15 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6287640
• 关键词: DNA damage; binding proteins; blood glucose; blood lipid; breast neoplasms; clinical research; female; hormone regulation /control mechanism; human subject; human therapy evaluation; insulin; insulinlike growth factor; leptin; longitudinal human study; neoplasm /cancer genetics; neoplasm /cancer nutrition therapy; nutrition related tag; obesity; triglycerides; weight loss; women's health

Obesity has been shown to be associated with a poor prognosis in breast cancer patients. Survival time is decreased and recurrence rates are increased with greater obesity. Whether or not weight loss can have favorable effects on prognosis in obese breast cancer survivors is not known, and that is the ultimate question we would like to ask. As a first step, effective methods for weight loss need to be established in this population. We started a pilot study with internal funds develop an individualized approach towards weight loss in obese breast cancer survivors, and preliminary data is encouraging. We would like to be able to extend this study for a full 18 months and analyze the blood samples that are being collected for markers of cancer risk. Forty eight obese cancer survivors have been enrolled. At baseline, a psychiatric evaluation was obtained for each women and questionnaires on diet, health, exercise and psychosocial factors were administered. Since we are asking women to make large lifestyle changes, we would like to extend the intervention for a full year (instead of 6 months) and add a 6-month follow-up point to examine maintenance of weight loss. A better understanding of the influence of behavioral factors on weight loss should help us design a successful larger study with recurrence as the endpoint. As a secondary aim, we propose to analyze the blood samples collected for markers of cancer risk which are expected to be affected by weight loss: oxidative DNA damage, insulin-like growth factor 1 (IGF-1), and IGF-binding protein 3. The extent of changes in these markers will be compared with other plasma measures that are known to be affected by weight loss: leptin, glucose, lipids and triglyceride levels. This study should be useful to determine certain psychosocial are associated with extent of weight loss, and in turn whether weight loss is associated with changes in selected markers of breast cancer risk.

肥胖已显示与乳腺癌患者的预后不良有关。生存时间降低，随着肥胖的更大，复发率会增加。体重减轻是否会对肥胖乳腺癌幸存者的预后产生有利的影响，这是我们想提出的最终问题。作为第一步，需要在该人群中建立有效的减肥方法。我们通过内部资金开始了一项试点研究，在肥胖的乳腺癌幸存者中开发了一种个性化的减肥方法，而初步数据令人鼓舞。我们希望能够将这项研究延长整整18个月，并分析正在收集的癌症风险标记的血液样本。已经招募了48个肥胖的癌症幸存者。在基线时，对每位妇女进行了精神病评估，并进行了有关饮食，健康，运动和社会心理因素的问卷。由于我们要求妇女改变大规模的生活方式，因此我们希望将干预措施延长一年（而不是6个月），并增加6个月的随访点以检查减肥的维持。 更好地理解行为因素对体重减轻的影响应有助于我们以终点的重复设计成功的大型研究。作为次要目的，我们建议分析收集的癌症风险标记的血液样本，这些标志将受体重减轻的影响：氧化性DNA损伤，胰岛素样生长因子1（IGF-1）和IGF结合蛋白3。这项研究对于确定某些心理社会的体重减轻程度应该有用，而体重减轻是否与乳腺癌风险选定标记的变化有关。