Genetic Influences on the Overlap Between Internalizing and Alcohol Problems

遗传对内化和酒精问题重叠的影响

基本信息

批准号：
8153116
负责人：
ALEXIS C EDWARDS
金额：
$ 5.26万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-27 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8153116
关键词：
Address Affect Aggressive behavior Agoraphobia Alcohol abuse Alcohol consumption Alcohol dependence Alcohols Anxiety Disorders Architecture Area Behavioral Behavioral Genetics Biological Models C10 Categories Comorbidity Complex Data Development Diagnosis Diagnostic Disease Drosophila genus Drosophila melanogaster Environmental Risk Factor Epidemiologic Methods Epidemiologic Studies Epidemiology Equation Genes Genetic Genetic Research Genetic Risk Genetic Structures Genomics Goals Human Human Genetics Individual Literature Major Depressive Disorder Measures Mental Depression Methods Modeling Mood Disorders National Institute on Alcohol Abuse and Alcoholism Panic Disorder Pathway interactions Phenotype Population Prevention Process Research Research Support Research Training Social Phobia Staging Structure Symptoms Techniques Testing Training Translational Research Twin Multiple Birth Twin Studies Variant Work alcohol misuse alcohol use disorder genetic analysis genetic epidemiology genetic variant genome wide association study improved psychogenetics public health relevance skills tool training project trait

项目摘要

DESCRIPTION (provided by applicant): Project Summary: The broad research objective of the proposed project is to investigate the relationship between internalizing symptoms and alcohol problems. Specifically, this will entail an analysis of the genetic and environmental liability shared across traits and an effort to identify genetic variants influencing this association. One component of the project will address these goals through the use of genetic epidemiology. By studying the relationship between these traits in a population of twins, it is possible to partition variance into that which is attributable to genetic versus environmental factors. Using measures of internalizing symptoms (across multiple disorders) and alcohol problems, the research described in this proposal will address questions about the degree to which shared latent genetic liability influences the association between these traits, and whether that shared liability is specific to particular manifestations of internalizing (such as symptoms of major depression, or symptoms of social phobia) or is common across internalizing phenotypes. The second component of the project builds on results from the twin component. Using information about the structure of genetic influences common to internalizing symptoms and alcohol misuse, a single quantitative phenotype will be constructed that approximates an individual's genetic liability to overlap between internalizing and alcohol problems. This phenotype will be used as the dependent variable in a genome-wide association study, with the goal of identifying genetic variants associated with the composite phenotype. PUBLIC HEALTH RELEVANCE: Project Narrative: Research initiatives of the NIAAA include delineation of genetic and behavioral vulnerability to alcohol use and disorders. The proposed project will improve understanding of the latent and specific genetic influences on an internalizing pathway to alcohol use. This information can be used to guide treatment and prevention of both internalizing disorders and alcohol use disorders.

描述（由申请人提供）：项目摘要：拟议项目的广泛研究目标是调查内在症状与酒精问题之间的关系。具体而言，这将需要对跨性状共同的遗传和环境责任进行分析，并努力确定影响这种关联的遗传变异。该项目的一个组成部分将通过使用遗传流行病学来解决这些目标。通过研究双胞胎人群中这些特征之间的关系，可以将差异分为遗传因素与环境因素的差异。使用内部症状（跨多种疾病）和酒精问题的措施，本提案中描述的研究将解决有关共同的潜在遗传负债影响这些特征之间关联的程度，以及这种共同负债是否针对内在化的特定表现（例如，社交phobia的重大抑郁症或社交phobia症状）或在内部化苯甲酸含量中常见。项目的第二个组成部分是基于双重组件的结果。使用有关内在症状和滥用酒精的遗传影响结构的信息，将构建单个定量表型，该表型将近似于个人的遗传责任，以重叠内在化和酒精问题之间。该表型将用作全基因组关联研究中的因变量，其目的是识别与复合表型相关的遗传变异。公共卫生相关性：项目叙述：NIAAA的研究计划包括鉴定遗传和行为脆弱性对酒精的使用和疾病。拟议的项目将提高对潜在和特定遗传影响对饮酒途径的潜在遗传影响的理解。这些信息可用于指导和预防内部化障碍和酒精使用障碍。