Training in the Biology of Injury and Inflammation

损伤和炎症生物学培训

• 批准号: 8127659
• 负责人: Jeffrey H. Lawson
• 金额: $ 12.71万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8127659
• 关键词: Biology; Inflammation; Injury; Training

DESCRIPTION (provided by applicant): Injury and inflammation are central components of a variety of pathophysiologic states, such as sepsis, trauma, hemorrhage, systemic inflammatory response syndrome, arthritis and atherosclerosis. The biology of injury and inflammation shares many common themes across disease states. While trauma was initially deemed to be the realm of the surgeon, arthritis the purview of the rheumatologist, and atherosclerosis the focus for the cardiologist, these processes merely represent specific examples of injury with an accompanying host inflammatory response. Indeed, the molecular and cellular basis for many of these disorders are highly analogous. These biological questions are sufficiently complex that sophisticated techniques in immunology, ceil biology, biochemistry, and molecular biology are required. Crossing the boundaries of traditional scientific and clinical disciplines to address these issues of injury and inflammation will require that future researchers are trained in a multi-disciplinary environment with the opportunity for cross fertilization of ideas and technologies. The purpose of this training grant in the Biology of Injury and Inflammation is to provide postdoctoral research training in the cellular and molecular biology of clinical states typified by trauma, sepsis, ischemia/reperfusion, acute and chronic inflammation, and/or critical illness. We are proposing to support 4 total trainees per year. Each trainee will spend at least two years as apostdoctoral research fellow. This application represents a multidisciplinary research training program which draws from the basic science departments of Immunology, Biochemistry, Genetics, and Biomedical Engineering, as well as the clinical departments of Medicine, Anesthesiology, and Surgery. Although this grant will be housed in the Duke Dept. of Surgery, applications from interested individuals in Anesthesiology, Medicine or the basic sciences are welcome. The central intent of this program is to train future scientists in the Biology of Injury and Inflammation. Relevance: It is our goal to capitalize upon the scientific opportunities and resources available through Duke University by training future leaders in the biology of injury and inflammation.

描述（由申请人提供）：损伤和炎症是多种病理生理状态的中心成分，例如败血症，创伤，出血，全身性炎症反应综合征，关节炎和动脉粥样硬化。损伤和炎症的生物学在疾病状态下具有许多常见的主题。虽然创伤最初被认为是外科医生的领域，关节炎是风湿病学家的权限，而动脉粥样硬化是心脏病专家的重点，但这些过程仅代表了伴随宿主炎症反应的特定损伤例子。实际上，许多这些疾病的分子和细胞基础高度相似。这些生物学问题非常复杂，需要在免疫学，CEIL生物学，生物化学和分子生物学方面采用复杂的技术。越过传统的科学和临床学科的界限以解决这些伤害和炎症问题，将要求在多学科环境中对未来的研究人员进行培训，并有机会交叉施肥思想和技术。这项培训赠款在损伤和炎症生物学中的目的是在以创伤，败血症，缺血/再灌注，急性和慢性炎症和/或严重疾病为代表的临床状态的细胞和分子生物学中提供博士后研究培训。我们建议每年支持4个总学员。每个学员将至少两年作为Apostdoctoral研究研究员。该应用程序代表了一项多学科研究培训计划，该计划借鉴了免疫学，生物化学，遗传学和生物医学工程以及医学，麻醉和手术的临床部门的基础科学系。尽管这笔赠款将安置在杜克大学外科部，但欢迎有兴趣的人在麻醉，医学或基础科学方面的申请。该计划的核心目的是培训未来的科学家损伤和炎症生物学。 相关性：我们的目标是通过培训未来的损伤和炎症生物学领导者来利用杜克大学获得的科学机会和资源。