Quantitative MRI of Iron Homeostasis, Atrophy and Tissue Structure in AD Brain

AD 脑中铁稳态、萎缩和组织结构的定量 MRI

• 批准号: 8209254
• 负责人: JOSEPH A. HELPERN
• 金额: $ 42.82万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-15 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8209254
• 关键词: Address; Affect; Age; Alzheimer' s Disease; Anisotropy; Appearance; Atrophic; Axon; Biological Markers; Brain; Brain region; Cell Density; Cell membrane; Clinical; Complex; Cross-Sectional Studies; Dementia; Diagnosis; Differential Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; Doctor of Philosophy; Early treatment; Elderly; Evaluation; Future; Goals; Homeostasis; Image; Impaired cognition; Incidence; Individual; Intervention; Iron; Laboratories; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Medial; Monitor; Neurodegenerative Disorders; Onset of illness; Pathogenesis; Pathology; Patients; Persons; Prevalence; Quantitative Evaluations; Research Personnel; Risk; Space Perception; Staging; Structure; Surrogate Markers; Techniques; Temporal Lobe; Testing; Therapeutic; Therapy Clinical Trials; Tissues; United States; Work; acronyms; brain tissue; cerebral atrophy; clinical Diagnosis; clinically relevant; density; drug discovery; frontal lobe; indexing; interest; magnetic field; mild neurocognitive impairment; novel; pre-clinical; programs

项目成果

Progress in diffusion-weighted imaging: concepts, techniques and applications to the central nervous system.

弥散加权成像的进展：概念、技术及其在中枢神经系统中的应用。

• DOI: 10.1002/nbm.1589
• 发表时间: 2010
• 期刊: NMR in biomedicine
• 影响因子: 2.9
• 作者: Jensen,JensH;Helpern,JosephA
• 通讯作者: Helpern,JosephA

Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction.

• DOI: 10.1002/nbm.1610
• 发表时间: 2011-06
• 期刊: NMR IN BIOMEDICINE
• 影响因子: 2.9
• 作者: Jensen, Jens H.;Falangola, Maria F.;Hu, Caixia;Tabesh, Ali;Rapalino, Otto;Lo, Calvin;Helpern, Joseph A.
• 通讯作者: Helpern, Joseph A.

MRI quantification of non-Gaussian water diffusion by kurtosis analysis.

• DOI: 10.1002/nbm.1518
• 发表时间: 2010-08
• 期刊: NMR IN BIOMEDICINE
• 影响因子: 2.9
• 作者: Jensen, Jens H.;Helpern, Joseph A.
• 通讯作者: Helpern, Joseph A.

Preliminary evidence of altered gray and white matter microstructural development in the frontal lobe of adolescents with attention-deficit hyperactivity disorder: a diffusional kurtosis imaging study.

• DOI: 10.1002/jmri.22397
• 发表时间: 2011-01
• 期刊: JOURNAL OF MAGNETIC RESONANCE IMAGING
• 影响因子: 4.4
• 作者: Helpern, Joseph A.;Adisetiyo, Vitria;Falangola, Maria F.;Hu, Caixia;Di Martino, Adriana;Williams, Kathleen;Castellanos, Francisco X.;Jensen, Jens H.
• 通讯作者: Jensen, Jens H.

Leading non-Gaussian corrections for diffusion orientation distribution function.

• DOI: 10.1002/nbm.3053
• 发表时间: 2014-02
• 期刊: NMR IN BIOMEDICINE
• 影响因子: 2.9
• 作者: Jensen, Jens H.;Helpern, Joseph A.;Tabesh, Ali
• 通讯作者: Tabesh, Ali