Quantitative MRI of Microstructure and Iron Homeostasis in ADHD Brain

ADHD 大脑微结构和铁稳态的定量 MRI

• 批准号: 8144718
• 负责人: JOSEPH A. HELPERN
• 金额: $ 47.61万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8144718
• 关键词: Address; Adolescent; Adult; Aftercare; Age; American Psychiatric Association; Anatomy; Anisotropy; Anterior; Architecture; Attention deficit hyperactivity disorder; Axon; Biological; Brain; Brain region; Cell Density; Cell membrane; Child; Child Mental Health; Child Psychiatry; Childhood; Clinical; Corpus striatum structure; Correlation Studies; Cross-Sectional Studies; Data; Development; Developmental Delay Disorders; Diagnosis; Dietary Iron; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Dopamine; Dorsal; Double-Blind Method; Exhibits; Ferritin; Forcep; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Gender; Goals; High Prevalence; Homeostasis; Image; Impairment; Investigation; Iron; Lead; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Medial; Mediating; Metric; Modeling; Monitor; Neurobiology; Parietal; Pattern; Physical shape; Prefrontal Cortex; Process; Radial; Reporting; Research Personnel; Role; Sample Size; Serum; Severities; Severity of illness; Space Perception; Specific qualifier value; Supplementation; Symptoms; Techniques; Testing; Thick; Time; Tissues; age related; base; brain tissue; cingulate cortex; density; design; early adolescence; gray matter; harpin; improved; in vivo; indexing; interest; longitudinal design; magnetic field; myelination; neural circuit; neurophysiology; parietal-frontal circuits; placebo controlled study; relating to nervous system; white matter

项目成果

Attention-deficit/hyperactivity disorder without comorbidity is associated with distinct atypical patterns of cerebral microstructural development.

无合并症的注意力缺陷/多动障碍与大脑微结构发育的独特非典型模式相关。

• DOI: 10.1002/hbm.22317
• 发表时间: 2014-05
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Adisetiyo, Vitria;Tabesh, Ali;Di Martino, Adriana;Falangola, Maria F.;Castellanos, Francisco X.;Jensen, Jens H.;Helpern, Joseph A.
• 通讯作者: Helpern, Joseph A.

Brain iron: a promising noninvasive biomarker of attention-deficit/hyperactivity disorder that warrants further investigation.

脑铁：一种有前景的注意力缺陷/多动症非侵入性生物标志物，值得进一步研究。

• DOI: 10.2217/bmm.15.9
• 发表时间: 2015
• 期刊: Biomarkers in medicine
• 影响因子: 2.2
• 作者: Adisetiyo,Vitria;Helpern,JosephA
• 通讯作者: Helpern,JosephA