Reaearch Methods (Neuroimaging Core)

研究方法（神经影像核心）

• 批准号: 8099709
• 负责人: STEPHEN M STRAKOWSKI
• 金额: $ 41.95万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8099709
• 关键词: Administrator; Biometry; Bipolar Disorder; Businesses; Clinical; Clinical assessments; Cognitive; Computer software; Core Facility; Data; Data Analyses; Data Set; Development; Engineering; Ensure; Faculty; Functional Magnetic Resonance Imaging; Future; Goals; Image; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Methods; Mission; NIH Program Announcements; Physicians; Principal Investigator; Research; Research Methodology; Spectrum Analysis; System; Techniques; Time; Universities; Work; base; computerized data processing; imaging modality; neuroimaging; neuropsychological; new technology; novel; operation; research study; spectroscopic imaging; technology development; tool

The Neuroimaging Core (NIC) fulfills the requirement for a "Research Methods Core" described in the CIDAR Program Announcement (PA05-039); the NIC will provide Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) to the BITREC. The NIC will be based in the University of Cincinnati (UC) Center for Imaging Research (CIR). The CIR employs a number of physicians, MR physicists and neuroscientists, as well as a business administrator, MR engineer, MR technician, software programmer, and IT technician to support its day-to-day operations. Dr. Lee, an Associate Director and the senior physicist of the CIR, will be the Director of the NIC. He will oversee overall core function and novel technology development. He will also supervise any MRI system upgrades to ensure that these do not impact on our ability to achieve BITREC objectives. The NIC will be organized into two divisions reflecting its primary activities. The MRS division, directed by Dr. Komoroski, with Dr. Chu serving as Assistant Director, will provide for MRS technical development, data processing, and data analysis for the BITREC. The MRI division, directed by Dr. Eliassen, will provide for fMRI data processing and analysis as well as for the development of novel neuropsychological probes required by the BITREC. NIC faculty will also work with the Biostatistics Division of the Operations and Clinical Assessment Core in order to develop novel methods to integrate and analyze clinical and imaging datasets. The NIC faculty will work closely with project principal investigators to properly apply imaging methods to accomplish the proposed specific aims. In addition to this primary responsibility, as a core facility, the NIC will also develop novel techniques to support current and future missions of the BITREC. These will include developing fully automated real-time fMRI guided MR spectroscopy for integrating fMRI and MRS data; 31P-MRS multivoxel techniques; and developing novel cognitive probes for advanced fMRI research and the study of bipolar disorder. The NIC will provide common imaging and spectroscopic tools, thereby permitting comparisons across projects, as well as supporting each project's specific goals. By so doing, the NIC provides another means of integrating activities within the proposed BITREC.

神经影像核（NIC）满足了对“研究方法核心”的要求 CIDAR计划公告（PA05-039）; NIC将提供磁共振成像（MRI）和 光谱法（MRS）到BITREC。 NIC将位于辛辛那提大学（UC）中心 成像研究（CIR）。 CIR雇用了许多医生，物理学家和神经科学家，作为 以及业务管理员，工程师先生，技术人员，软件程序员和IT技术人员 支持其日常运营。 CIR的副主任兼高级物理学家Lee博士将是 NIC的导演。他将监督整体核心功能和新颖的技术发展。他也会 监督任何MRI系统升级，以确保这些升级不会影响我们实现BITREC的能力 目标。 NIC将分为反映其主要活动的两个部门。夫人部门 由Komoroski博士指导的，Chu博士担任助理董事，将为Technology Mrs Technology提供 BITREC的开发，数据处理和数据分析。由Eliassen博士执导的MRI部门， 将提供fMRI数据处理和分析以及新颖的发展 BITREC要求的神经心理学探针。 NIC教师还将与生物统计局合作 运营和临床评估核心的核心，以开发新的方法来整合和分析 临床和成像数据集。 NIC教师将与项目首席调查员紧密合作以正确 应用成像方法来实现提出的特定目标。除了这一主要责任， 作为核心设施，NIC还将开发新技术来支持当前和未来的任务 Bitrec。这些将包括开发全自动实时fMRI指导的MR光谱法以进行 集成fMRI和MRS数据； 31p-MRS多毒素技术；并开发新颖的认知探针 高级功能磁共振成像研究和双相情感障碍研究。 NIC将提供常见的成像和 光谱工具，从而允许在项目之间进行比较，并支持每个项目的 具体目标。通过这样做，NIC提供了将活动整合到拟议中的另一种方法 Bitrec。