Special Scientific Procedures ( Longitudinal Assessment ) Core

特别科学程序（纵向评估）核心

• 批准号: 8099710
• 负责人: STEPHEN M STRAKOWSKI
• 金额: $ 29.94万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8099710
• 关键词: Affective; Benchmarking; Bipolar Disorder; Clinical; Elements; Enrollment; Ensure; Human Resources; Longitudinal Studies; Measures; Patients; Pharmacology; Procedures; Psychiatry; Qualifying; Reporting; Research; Research Infrastructure; Structure; Symptoms; Syndrome; Time; clinical care; experience; infrastructure development; meetings; neuroimaging; professor; research clinical testing; response; success; treatment response

Bipolar disorder is a dynamic illness with constantly changing symptom and syndrome presentations that confound interpretation of neuroimaging findings, as well as treatment response. This feature of the illness raises the need to examine patients as the condition evolves over time in order to clarify interactions between neuroimaging measures, clinical response and affective state. Careful longitudinal assessments and subject retention are critical elements to the success of the BITREC and its proposed projects. The Longitudinal Assessment Core (LAC) will serve this need and is a direct extension of over a decade of experience following young bipolar patients. Specifically, our experience with longitudinal studies is demonstrated by the success of a number of large, long-term projects. Our previous and ongoing projects provide an infrastructure for the longitudinal study of bipolar disorder from which the LAC will be developed. The LAC will be fully integrated with the other BITREC cores and projects as described in the Operational Plan. Dr. Paul Keck, Professor of Psychiatry and Pharmacology and Vice-Chair for Research in the Department of Psychiatry will direct the LAC. He will be responsible for overall core function and for overseeing infrastructure development. He will be assisted by several clinicians and staff to provide excellent clinical care and ongoing assessments to subjects enrolled in the BITREC. The LAC will hold staff meetings every other week to ensure that recruitment benchmarks are being met and to review subjects who have developed new affective episodes or symptoms in order to determine whether they qualify for additional BITREC projects. Standard operating procedures will be developed to maximize efficiency and meet objectives and benchmarks. Most decisions involving daily core function will be made by the personnel of the core under the direction of Dr. Keck. These decisions will be guided by and reported to the BITREC Steering Committee. Additionally, Dr. Keck will be integrated within the overall administrative structure of the BITREC by serving on the Steering Committee. With this structure established the LAC will be able to meet its primary functions which are: 1) to provide treatment to subjects actively participating in BITREC projects; 2) to provide ongoing clinical evaluations and excellent clinical care to subjects enrolled in the BITREC between projects; and 3) to identify subjects who meet criteria for a new BITREC project. By following and managing subjects across project, the LAC helps to further integrate the various components of the BITREC, assuring a cohesive and effective research center.

躁郁症是一种动态疾病，症状和综合征不断变化 神经影像学发现以及治疗反应的混淆解释。疾病的这一特征 随着时间的流逝，随着病情的发展以澄清相互作用，需要检查患者的需求 在神经影像措施，临床反应和情感状态之间。仔细的纵向评估 主题保留是BITREC及其拟议项目成功的关键要素。这 纵向评估核心（LAC）将满足这一需求，并且是十多年来的直接扩展 年轻双极患者的经验。具体来说，我们在纵向研究方面的经验是 通过许多大型长期项目的成功证明。我们以前正在进行的项目 为将开发出乳液的纵向研究提供基础设施。 LAC将与操作中所述的其他BITREC内核和项目完全集成 计划。 Paul Keck博士，精神病学和药理学教授，以及研究副主席 精神病学系将指导LAC。他将负责总体核心功能和 监督基础设施的发展。他将得到几位临床医生和员工的协助，以提供出色的 对BITREC参加的受试者的临床护理和持续评估。 LAC将举行员工会议 每隔一周，以确保满足招聘基准并审查拥有的主题 开发了新的情感发作或症状，以确定它们是否有资格 BITREC项目。标准操作程序将开发以最大化效率并达到满足 目标和基准。涉及每日核心功能的大多数决定将由 凯克博士的指导下的核心。这些决定将由BITREC转向指导并报告 委员会。此外，凯克博士将集成到BITREC的整体管理结构中 通过指导委员会任职。建立了这种结构，LAC将能够满足其 主要功能是：1）为积极参与BITREC项目的受试者提供治疗； 2）为BITREC的受试者提供持续的临床评估和出色的临床护理 之间的项目； 3）确定符合新BITREC项目标准的受试者。通过跟随和 LAC在整个项目中管理主题，有助于进一步整合Bitrec的各个组件， 确保有凝聚力有效的研究中心。