Hypervigilance versus perceptual avoidance in social phobia

社交恐惧症中的过度警惕与知觉回避

基本信息

批准号：
8053390
负责人：
Andreas Keil
金额：
$ 23.63万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8053390
关键词：
Address Anxiety Anxiety Disorders Attention Behavioral Brain Chronic Cognitive Cognitive Therapy Cues Data Diagnosis Diagnostic Diagnostic Specificity Disease Elements Emotional Etiology Event Evidence based intervention Exposure to Eye Movements Fright Functional disorder Galvanic Skin Response Goals Health Heart Rate Individual Intervention Laboratories Maintenance Measures Mental Depression Mental Health Methodology Methods Nature Outcome Participant Patient Self-Report Patients Pattern Perception Peripheral Pharmaceutical Preparations Physiological Predictive Value Process Psychopathology Psychophysiology Reflex action Reporting Research Resistance Resource Allocation Resources Role Sampling Selection for Treatments Selective Serotonin Reuptake Inhibitor Severities Social Phobia Specific Phobia Stimulus Symptoms Testing Therapeutic Time Training Treatment outcome Visual Visual evoked cortical potential Work base clinical anxiety improved indexing neurobehavioral neuroimaging neurophysiology outcome forecast panic disorder with agoraphobia prognostic prognostic indicator response selective attention social success therapy outcome vigilance visual stimulus

项目摘要

DESCRIPTION (provided by applicant): Social phobia has been related to dysfunctions of attention allocation that include hyper-vigilance and subsequent perceptual avoidance of social threat cues. This hypothesized deficit has been difficult to test using behavioral and/or neurophysiological measures because continuous, near real-time measures of resource deployment were not available so far, and the covert processes of attention orienting can not be measured by means of behavioral approaches. The research proposed here directly addresses this difficulty, examining the time course of attentional resource allocation by means of steady-state visual evoked potentials (ssVEPs), evoked by flickering visual stimuli. This electroencephalographic (EEG) measure uniquely provides for a near real-time assessment of visual selective attention. The overall goal of the proposed research is to identify the role of dysfunctional attention to social threat cues in the psychopathology of social phobia. It is planned to determine whether individuals characterized by high social fear or by social phobia direct perceptual and attentional resources towards or away from social threat stimuli, and in what temporal order they do so. Combining the ssVEP approach with self-report, behavioral, and physiological measures, we first aim to quantify the relationship between attention dynamics and the intensity of then aim to study the relationship between dysfunctional attention dynamics and the severity of social phobia during social threat cue processing. Finally, we plan to assess the predictive value of ssVEP-based attention dynamics as prognostic assessment attention. This information has strong implications for improving treatment selection and outcome prognosis. Specifically, matching patients to exposure-based or cognitive treatments will benefit from information as to the nature of their hypervigilance vis-¿-vis avoidance of social threat cues. PUBLIC HEALTH RELEVANCE: Social phobia has been related to dysfunctions of attention allocation that may include chronic hyper-vigilance and subsequent perceptual avoidance of social threat cues. The research proposed here directly addresses the neurobehavioral mechanisms of such a deficit. It examines the time course of attentional resource allocation in relation to symptom severity of social phobia, and as a predictor of treatment outcome. This information has implications for improving treatment selection and outcome prognosis. Specifically, matching patients to exposure-based or cognitive treatments will benefit from information as to the nature of their hypervigilance vis-¿-vis avoidance of social threat cues.

描述（由申请人提供）：社交恐惧症与注意力分配功能障碍有关，包括过度警惕和随后对社交威胁线索的知觉回避，这种利用的缺陷很难使用行为和/或神经生理学措施进行测试，因为这种缺陷是连续的、近乎的。迄今为止，还没有资源部署的实时测量，并且无法通过行为方法来测量注意力定向的隐蔽过程，本文提出的研究直接解决了这一难题，研究了注意力资源分配的时间过程。通过由闪烁视觉刺激诱发的稳态视觉诱发电位（ssVEP），这种脑电图（EEG）测量独特地提供了视觉选择性注意力的近实时评估。对社会威胁线索的功能失调的注意在社交恐惧症的精神病理学中的作用计划确定以高度社交恐惧或社交恐惧为特征的个体是否将感知和注意力资源导向或远离社会威胁刺激。将 ssVEP 方法与自我报告、行为和生理测量相结合，我们首先旨在量化注意力动态与注意力强度之间的关系，然后旨在研究功能失调的注意力动态与注意力的严重程度之间的关系。最后，我们计划评估基于 ssVEP 的注意力动态作为预后评估注意力的预测价值，特别是，将患者与基于暴露的或预后相匹配。治疗将从有关其过度警惕的性质的信息中受益 - ¿ - 回避社会威胁线索：社交恐惧症与注意力分配功能障碍有关，其中可能包括长期过度警惕和随后对社会威胁线索的知觉回避。它检查了与社交恐惧症症状严重程度相关的注意力资源分配的时间过程，并作为治疗结果的预测因子，该信息对于改善治疗选择和结果预后具有重要意义。具体来说，将患者与基于暴露或认知的治疗相匹配将受益于有关他们过度警惕的性质的信息。 -避免社会威胁线索。

项目成果

期刊论文数量（26）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Interaural attention modulates outer hair cell function.

DOI：
10.1111/ejn.12746
发表时间：
2014-12
期刊：
The European journal of neuroscience
影响因子：
0
作者：
Srinivasan S;Keil A;Stratis K;Osborne AF;Cerwonka C;Wong J;Rieger BL;Polcz V;Smith DW
通讯作者：
Smith DW

Face-evoked steady-state visual potentials: effects of presentation rate and face inversion.

DOI：
10.3389/fnhum.2012.00316
发表时间：
2012
期刊：
Frontiers in human neuroscience
影响因子：
2.9
作者：
Gruss LF;Wieser MJ;Schweinberger SR;Keil A
通讯作者：
Keil A

Neural substrate of the late positive potential in emotional processing.

DOI：
10.1523/jneurosci.3109-12.2012
发表时间：
2012-10-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Liu Y;Huang H;McGinnis-Deweese M;Keil A;Ding M
通讯作者：
Ding M

Sustained preferential processing of social threat cues: bias without competition?