PAROXETINE & SILDENAFIL ON PHARMACOKINETICS OF METOPROLOL, CARVEDILOL, & ATENOLO

帕罗西汀

• 批准号: 7376597
• 负责人: Barry E Bleske
• 金额: $ 7.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376597
• 关键词: antidepressants; antihypertensive agents; beta antiadrenergic agent; blood pressure; drug interactions; emotions; heart rate; lead; paroxetine; thinking

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are many drug interactions that are thought to occur but are not well described. This includes drug interactions between a class of drugs called beta-blockers (for this study these drugs will include metoprolol, metoprolol extended release, carvedilol, and atenolol) and two other drugs, an antidepressant called paroxetine (Paxil) and a drug for sexual dysfunction called sildenafil (Viagra). For this study, normal volunteers will be recruited. Subjects will be randomly assigned to study groups. The primary outcomes will be changes in how the different beta-blockers are eliminated from the body when administered with the interacting drugs (Paxil and Viagra) and how the interacting drugs may affect beta blocker effects on heart rate and blood pressure The results of this study will lead to a better understanding on how to use these drugs together to treat patients more safely.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。有许多药物相互作用被认为会发生，但没有得到很好的描述。这包括一类称为 β 受体阻滞剂的药物（在本研究中，这些药物将包括美托洛尔、美托洛尔缓释剂、卡维地洛和阿替洛尔）与其他两种药物（一种称为帕罗西汀 (Paxil) 的抗抑郁药和一种治疗性功能障碍的药物）之间的药物相互作用。称为西地那非（伟哥）。本研究将招募普通志愿者。受试者将被随机分配到研究组。主要结果将是当与相互作用的药物（帕罗西汀和伟哥）一起服用时，不同的β受体阻滞剂从体内消除的方式发生变化，以及相互作用的药物如何影响β受体阻滞剂对心率和血压的影响。将有助于更好地了解如何一起使用这些药物来更安全地治疗患者。