ANTIHYPERTENSIVE DRUG USE AND FUNCTIONING IN THE ELDERLY

老年人抗高血压药物的使用和功能

• 批准号: 3118524
• 负责人: L DOUGLAS RIED
• 金额: $ 11.4万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-01 至 1993-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3118524
• 关键词: antidepressants; antihypertensive agents; beta antiadrenergic agent; body physical activity; cardiovascular disorder epidemiology; chemical information system; clinical depression; drug metabolism; human old age (65+); human therapy evaluation; hypertension; lifestyle; performance; questionnaires; sign /symptom; statistics /biometry

The goal of this proposal is to investigate the relationship between antihypertensive (AHT) drug use and physical functioning, health status, and medical care utilization in patients' later years. The study uses social, social psychological, medical status and utilization, physical functioning, and sociodemographic data from a three-wave health survey of the SHMO population. Medical utilization, health status and prescription drug use data will be obtained from medical and pharmacy records beginning one year prior to the survey. The specific aims of the project are to: 1) determine the exposure to AHT and antidepressant (ADT) drug use; 2) compare patient's ability to perform activities of daily living between groups of patients using different beta-blockers, especially focusing on comparisons between a) cardiospecific and non-cardiospecific and b) lipid soluble and non-lipid soluble drug products, and; 4) perform exploratory analyses to examine the relationship between a) high levels of depressive symptomatology b) exposure to ADT drug use and AHT drugs. The elderly study population will be the approximately 5,000 Medicare recipients enrolled in the SHMO demonstration project at Kaiser Permanente in Portland, OR as of July 1988. The basic approach begins with a description of the population and a comparison of the population in terms of the exposure rate to different AHT drug use. Analysis of variance will be used to examine the bivariate relationship between physical functioning and the different drug therapies. When the objective is to determine the separate and combined effects of the independent variables on the dependent variables, multivariate techniques including logistic and multiple regression will be used. The general approach will be to identify problems of the elderly that appear to be related to the use of various drugs and drug classes. This approach will be used to develop and demonstrate techniques to minimize or eliminate the problems.

该提案的目的是调查两者之间的关系 抗高血压（AHT）药物的使用和身体机能之间， 患者后期健康状况及医疗护理利用情况 年。 该研究利用社会、社会心理、医疗状况 和利用、身体机能和社会人口统计数据 来自 SHMO 人群的三波健康调查。 医疗的 使用情况、健康状况和处方药使用数据将 从一年前开始的医疗和药房记录中获得 到调查。 该项目的具体目标是：1) 确定 AHT 暴露和抗抑郁 (ADT) 药物使用情况； 2) 比较患者进行日常生活活动的能力 使用不同β受体阻滞剂的患者组之间， 特别关注 a) 心脏特异性和 非心脏特异性和 b) 脂溶性和非脂溶性药物 产品，以及； 4）进行探索性分析以检查 a) 高水平的抑郁症状之间的关系 b) 接触 ADT 药物和 AHT 药物。 老年人研究人口约为 5,000 参加 SHMO 示范项目的医疗保险受益人 截至 1988 年 7 月，位于俄勒冈州波特兰市的 Kaiser Permanente。基本情况 方法从对人口的描述和 人口接触率比较 不同的AHT药物使用。 方差分析将用于 检查身体机能之间的双变量关系 以及不同的药物治疗。 当目标是 确定独立因素的单独影响和综合影响 因变量的变量、多变量技术 将使用逻辑回归和多元回归。 这 一般方法是确定老年人的问题 似乎与各种药物和药物类别的使用有关。 该方法将用于开发和演示技术 以尽量减少或消除问题。