GENOMIC RESOURCES FOR IDENTIFYING GENES REGULATING SOCIAL BEHAVIOR

用于识别调节社会行为的基因的基因组资源

• 批准号: 8172407
• 负责人: Larry J Young
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172407
• 关键词: Breeding; Communities; Computer Retrieval of Information on Scientific Projects Database; Funding; Genes; Genetic; Genomics; Grant; Institution; Libraries; Microtus; Modeling; Polymorphic Microsatellite Marker; Quantitative Trait Loci; Regulation; Reporting; Research; Research Personnel; Resources; Social Behavior; Source; United States National Institutes of Health; Variant; genome-wide; mouse genome; neurobiological mechanism; novel; prairie vole; social attachment

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this project was to develop genomic resources for the prairie vole (Microtus ochrogaster) that would significantly enhance the value of this species as a model for understanding the genetic and neurobiological mechanisms governing social behavior. These resources will facilitate the discovery of novel genes involved in the regulation of social behavior and will be made freely available to the rapidly growing prairie vole research community. During the reporting period, we continued to add to the BAC genomice library for the prairie vole. We have created a genome-wide set of polymorphic microsatellite markers, to facilitate the discovery of novel genes contributing to variation in social behavior that will be useful in Quantitative Trait Locus (QTL) studies. We chose loci that could easily be anchored to the mouse genome. We continued to selectively breed prairie voles to establish lines that differ in their propensity to form social bonds.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的目标是开发草原田鼠（Microtus ochrogaster）的基因组资源，这将显着提高该物种作为理解控制社会行为的遗传和神经生物学机制的模型的价值。 这些资源将有助于发现参与社会行为调节的新基因，并将免费提供给快速发展的草原田鼠研究界。 报告期内，我们继续添加草原田鼠的BAC基因组库。 我们创建了一套全基因组多态性微卫星标记，以促进发现有助于社会行为变异的新基因，这将有助于数量性状基因座（QTL）研究。 我们选择了可以轻松锚定到小鼠基因组的基因座。 我们继续选择性地培育草原田鼠，以建立具有不同社会联系倾向的品系。