CENTER FOR AIDS RESEARCH

艾滋病研究中心

• 批准号: 8172317
• 负责人: JAMES W. CURRAN
• 金额: $ 13.16万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172317
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Behavioral Research; Biological Assay; Canada; Clinical; Clinical Research; Clinical Virology; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Drug usage; Equipment; Faculty; Flow Cytometry; Funding; Future; Gene Expression; Germany; Grant; Growth; HIV; HIV Infections; Home environment; Housing; Human immunodeficiency virus test; Immunity; Immunology; Immunophenotyping; India; Infection; Institution; International; Methods; Pathogenesis; Prevention; Quebec; Recruitment Activity; Research; Research Personnel; Resources; Science; Scientist; Secondary Prevention; Services; Source; Staining method; Stains; Training; Translational Research; United States National Institutes of Health; Universities; Vaccines; Viral Load result; cytokine; drug discovery; interest; member; pre-clinical; vaccine development; virology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center for AIDS Research (CFAR) at Emory has the primary purpose of facilitating conduct of scientifically rigorous basic, clinical, translational, and behavioral research in HIV/AIDS and to connect HIV/AIDS researchers within and across scientific fields. This continues to be accomplished through five HIV/AIDS research domains. These include Vaccine Development and Testing, HIV Pathogenesis and Drug Discovery, Clinical and Translational Research, Prevention Science, and, as an overarching domain, International Studies. Our objective was to facilitate the growth of NIHfunded research in the primary and secondary prevention of HIV and its aftermath. Of particular interest, the Immunology Core, housed at the Vaccine Center at Yerkes, successfully provided training in basic methods in immunophenotyping by flow cytometry, in ELISpot assays, and in intracellular cytokine staining assays to scientists from Canada (F. Fladin, Universite de Quebec, HIV infection in drug use), Germany (B. Bengsch, University of Germany, HCV/HIV co-infection), and India (V. Ramachandran and K. Murugarel, HIV infection and mucosla immunity). These positive interactions continue to produce future opportunities for collaboration between Emory and investigators from the trainees' home labs. The CFAR Pre-Clinical Virology Core, also housed at the Vaccine Center at Yerkes, provides valuable assay services to investigators, both within Emory and at other facilities. In addition to the viral load assays it has long performed, this unit now offers an array of gene expression assays, developed by this Core in the past year. Finally, the Virology Core provides training to those investigators who want to perform their own assays, and also makes its highly technical assay equipment available to these investigators. Through the strategic use of GRA funds, the CFAR was able to retain key faculty members, recruit junior faculty, and provide essential equipment to a number of Cores, including the Immunology, Virology and Drug Discovery, and Clinical Research Cores.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 埃默里大学艾滋病研究中心 (CFAR) 的主要目的是促进在艾滋病毒/艾滋病方面进行科学严谨的基础、临床、转化和行为研究，并将科学领域内和跨科学领域的艾滋病毒/艾滋病研究人员联系起来。 这继续通过五个艾滋病毒/艾滋病研究领域来完成。 这些包括疫苗开发和测试、艾滋病毒发病机制和药物发现、临床和转化研究、预防科学，以及作为一个总体领域的国际研究。我们的目标是促进 NIH 资助的艾滋病毒一级和二级预防及其后果研究的发展。 特别令人感兴趣的是，位于 Yerkes 疫苗中心的免疫学核心成功地为来自加拿大的科学家提供了流式细胞术免疫表型分型、ELISpot 测定和细胞内细胞因子染色测定基本方法的培训（F. Fladin，魁北克大学） ，吸毒中的 HIV 感染）、德国（B. Bengsch，德国大学，HCV/HIV 双重感染）和印度（V. Ramachandran 和 K. Murugarel、HIV 感染和粘膜免疫）。这些积极的互动继续为埃默里大学和受训者家庭实验室的研究人员之间的合作创造未来的机会。 CFAR 临床前病毒学核心也位于耶基斯疫苗中心，为埃默里大学和其他机构的研究人员提供有价值的检测服务。除了长期以来进行的病毒载量测定之外，该单位现在还提供该核心在过去一年开发的一系列基因表达测定。最后，病毒学核心为那些想要进行自己的检测的研究人员提供培训，并为这些研究人员提供其高科技检测设备。 通过战略性使用 GRA 资金，CFAR 能够留住关键教职人员，招募初级教职人员，并为许多核心提供必要的设备，包括免疫学、病毒学和药物发现以及临床研究核心。