NEURAL MECHANISMS OF SOCIAL COGNITION AND BONDING

社会认知和联系的神经机制

• 批准号: 8172403
• 负责人: Larry J Young
• 金额: $ 4.39万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172403
• 关键词: Amygdaloid structure; Animal Model; Autistic Disorder; Brain; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Cycloserine; Data; Drug Design; Female; Funding; Glutamate Agonist; Glutamates; Grant; Infusion procedures; Institution; Mental disorders; Nucleus Accumbens; Oxytocin; Pharmaceutical Preparations; Research; Research Personnel; Resources; Signal Transduction; Site; Source; United States National Institutes of Health; affiliative behavior; effective therapy; neuromechanism; prairie vole; preference; putamen; social attachment; social cognition

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We collected data demonstrating that the glutamate agonist, d-cycloserine facilitates social bond formation in prairie voles. D-cycloserine is a drug that has been used in clinical trials. We showed that peripherally administered D-cycloserine enhances partner preference formation in female prairie voles. This study was followed by site specific infusions the drug into the amygdala, nucleus accumbens and caudate putamen. Our results suggested that D-cycloserine infused into the nucleus accumbens and amygdala, but not into the caudate facilitates partner preference formation. These studies will have direct translational implications for designing drug treatments in autism. Prairie voles are an ideal animal model for investigating the brain mechanisms that regulate affiliative behavior and social bonding. We hypothesized that enhanced oxytocin and glutamate signaling in the brain may be an effective treatment for the disruption in social cognition in psychiatric disorders such as autism.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们收集了数据，表明谷氨酸激动剂D-胞糖烯促进了草原田鼠的社会纽带形成。 D-胞丝烯是一种已在临床试验中使用的药物。 我们表明，外围施用的D-胞丝烯可以增强雌性草原田鼠的伴侣偏好形成。 这项研究之后是部位特异性输注，该药物将药物投入到杏仁核，伏隔核和尾状壳中。 我们的结果表明，D-胞丝烯融入了伏隔核和杏仁核中，但不融入尾状核，有助于伴侣的偏好形成。 这些研究将对设计自闭症的药物治疗具有直接的翻译意义。 草原田鼠是研究调节隶属行为和社会联系的大脑机制的理想动物模型。 我们假设大脑中增强的催产素和谷氨酸信号传导可能是对自闭症等精神疾病中社会认知中断的有效治疗方法。