COMMON LIFE STRESSES & FERTILITY IN PRIMATES

常见的生活压力

• 批准号: 8173178
• 负责人: JUDY L CAMERON
• 金额: $ 4.76万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173178
• 关键词: Animals; Build-it; Computer Retrieval of Information on Scientific Projects Database; Fertility; Funding; Gene Expression; Grant; Individual; Infertility; Institution; Life Stress; Menstrual cycle; Neurons; Play; Primates; Research; Research Personnel; Resources; Role; Selective Serotonin Reuptake Inhibitor; Source; Stress; System; United States National Institutes of Health; Woman; hypothalamic-pituitary-adrenal axis; nonhuman primate; oocyte maturation; relating to nervous system; reproductive function; stress resilience

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project examines the role that everyday life stresses play in leading to infertility in women and nonhuman primates. It builds on our previous findings that some individuals are very sensitive to stress and readily show stress-induced suppression of reproductive function, while others are stress-resilient and maintain normal menstrual cycles when stressed. We have found that stress-sensitive individuals show lower activity of central serotonergic neurons compared to more stress-resilient individuals as shown both physiologically and by changes in gene expression. In this grant, Specific Aim 1 is to determine if treatment with a selective serotonin reuptake inhibitor (SSRI) will increase the stress resilience of stress-sensitive individuals. Specific Aim 2 is to identify differences in gene expression and activity of central neural systems in stress-sensitive and stress-resilient individuals. Specific Aim 3 examines the effects of stress on follicular and oocyte maturation in stress-sensitive and stress-resilient individuals. Specific Aim 4 examines activity of the hypothalamic-pituitary-adrenal (HPA) axis in stress-sensitive vs. stress-resilient animals.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目研究了日常生活压力在导致女性和非人类灵长类动物不孕中所起的作用。它建立在我们之前的发现之上，即一些人对压力非常敏感，并且很容易表现出压力引起的生殖抑制 功能，而另一些则具有抗压能力，并在压力下维持正常的月经周期。我们发现，与压力恢复能力更强的个体相比，压力敏感的个体表现出较低的中枢血清素能神经元活性，如下所示 生理学上和基因表达的变化。在这项资助中，具体目标 1 是确定选择性血清素再摄取抑制剂 (SSRI) 治疗是否会提高压力敏感个体的压力恢复能力。具体目标 2 是确定压力敏感和压力恢复个体的基因表达和中枢神经系统活动的差异。具体目标 3 检查压力对压力敏感和压力恢复个体的卵泡和卵母细胞成熟的影响。具体目标 4 检查应激敏感与应激恢复动物的下丘脑-垂体-肾上腺 (HPA) 轴的活动。