COMMON LIFE STRESSES & FERTILITY IN PRIMATES

常见的生活压力

• 批准号: 8357732
• 负责人: JUDY L CAMERON
• 金额: $ 3.63万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357732
• 关键词: Animals; Build-it; Fertility; Funding; Gene Expression; Grant; Individual; Infertility; Life Stress; Menstrual cycle; National Center for Research Resources; Neurons; Play; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; Selective Serotonin Reuptake Inhibitor; Source; Stress; System; United States National Institutes of Health; Woman; cost; hypothalamic-pituitary-adrenal axis; nonhuman primate; relating to nervous system; reproductive function; stress resilience

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project examines the role that everyday life stresses play in leading to infertility in women and nonhuman primates. It builds on our previous findings that some individuals are very sensitive to stress and readily show stress-induced suppression of reproductive function, while others are stress-resilient and maintain normal menstrual cycles when stressed. We have found that stress-sensitive individuals show lower activity of central serotonergic neurons compared to more stress-resilient individuals as shown both physiologically and by changes in gene expression. In this grant, Specific Aim 1 is to determine if treatment with a selective serotonin reuptake inhibitor (SSRI) will increase the stress resilience of stress-sensitive individuals. Specific Aim 2 is to identify differences in gene expression and activity of central neural systems in stress-sensitive and stress-resilient individuals. Specific Aim 3 examines activity of the hypothalamic-pituitary-adrenal (HPA) axis in stress-sensitive vs. stress-resilient animals.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目研究了日常生活压力在导致女性和非人类灵长类动物不孕中所起的作用。它建立在我们之前的发现基础上，即有些人对压力非常敏感，很容易表现出压力引起的生殖功能抑制，而另一些人则具有抗压能力，在压力下仍能维持正常的月经周期。我们发现，与压力恢复能力更强的个体相比，压力敏感的个体表现出较低的中枢血清素能神经元活性，这在生理学和基因表达的变化上都显示出来。在这项资助中，具体目标 1 是确定选择性血清素再摄取抑制剂 (SSRI) 治疗是否会提高压力敏感个体的压力恢复能力。具体目标 2 是确定压力敏感和压力恢复个体的基因表达和中枢神经系统活动的差异。具体目标 3 检查压力敏感与压力恢复动物的下丘脑-垂体-肾上腺 (HPA) 轴的活动。