BEHAVIORAL GENETICS

行为遗传学

• 批准号: 8172406
• 负责人: Mark E Wilson
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172406
• 关键词: Accounting; Affect; Aggressive behavior; Animals; Anxiety; Behavior; Behavioral; Behavioral Genetics; Body Weights and Measures; CRH gene; Candidate Disease Gene; Characteristics; Collection; Computer Retrieval of Information on Scientific Projects Database; Data; Disease; Eating Disorders; Environment; Environmental Risk Factor; Ethics; Funding; Genes; Genetic; Genetic Polymorphism; Glucose; Goals; Grant; Height; Heritability; Hormones; Hydrocortisone; Individual; Individual Differences; Institution; Insulin; Leptin; Life; Macaca mulatta; Measures; Mental Depression; Mental disorders; Modeling; Oxytocin; Pathology; Physiological; Population; Research; Research Personnel; Resources; Risk; Sampling; Serum; Source; Thyroxine; Triiodothyronine; United States National Institutes of Health; Vasopressins; addiction; adverse outcome; behavior measurement; biobehavior; genetic analysis; monoamine; social group; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Significant progress was made during the current funding period on the completion of this study. Socio-environmental factors significantly affect the risk for developing a number of behavioral and psychiatric disorders in people, including anxiety, depression, eating disorders, and addiction. It is becoming increasingly clear that some individuals are more susceptible to developing these pathologies and that this increased risk may be attributed to genetic factors. While identifying genetic/environment influences on behavior presents practical challenges and ethical constraints in people, rhesus monkeys represent an ideal model to begin to identify the genetic contribution to such disorders. The goal of this project is to conduct an analysis of the genetic heritabilities of a number of biobehavioral and physiological traits that are relevant for psychiatric disorders, followed by linkage and association analysis of candidate genes and gene polymorphisms that account for individual differences in these characteristics using the pedigreed rhesus monkey population living in large social groups at the Field Station. In the past year we completed the collection of the behavioral and physiological samples on the animals. These data included behavioral measures of sociality and aggression, anthropometric measures of body weight, height, BMI, and serum hormone measures of leptin, insulin, triiodothyronine, thyroxin, glucose, and cortisol; and CSF measures of monoamines, CRH, vasopressin, cortisol, and oxytocin. As of Jan 2010, we are awaiting the final results of the CSF analyzes at which point we will begin the heritability analyzes. This project represents a unique opportunity to conduct a translational, behavioral genetics study of candidate genes that predispose individuals to the adverse consequences associated with behavioral and psychiatric disorders, including anxiety and depression.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在本研究完成后，目前的资助期间取得了重大进展。 社会环境因素显着影响人们在包括焦虑，抑郁，饮食失调和成瘾的人们中发展多种行为和精神疾病的风险。 越来越清楚的是，有些人更容易受到这些病理的影响，并且这种增加的风险可能归因于遗传因素。 在确定遗传/环境对行为的影响列出了人们的实际挑战和道德约束，但恒河猴代表了一个理想的模型，开始识别对此类疾病的遗传贡献。 该项目的目的是对与精神疾病有关的许多生物行为和生理特征的遗传遗产进行分析，然后对候选基因和基因多态性进行连锁和关联分析，这些分析构成了这些特征在这些特征中使用幼儿园莫妮（Rhesus Monkey Monkey Monkey）居住在大型社交站的特征中的个人差异。 在过去的一年中，我们完成了动物行为和生理样本的收集。 这些数据包括社会性和侵略性的行为度量，人体体重，身高，BMI和血清激素的人体测量指标，用于瘦素，胰岛素，三碘甲醇，甲状腺素，葡萄糖，葡萄糖和皮质醇；以及单胺，CRH，加压素，皮质醇和催产素的CSF测量。 截至2010年1月，我们正在等待CSF分析的最终结果，此时我们将开始进行遗传性分析。 该项目代表了对候选基因进行翻译，行为遗传学研究的独特机会，该研究使个人倾向于与行为和精神疾病有关的不利后果，包括焦虑和抑郁症。