BEHAVIORAL GENETICS

行为遗传学

• 批准号: 8172406
• 负责人: Mark E Wilson
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172406
• 关键词: Accounting; Affect; Aggressive behavior; Animals; Anxiety; Behavior; Behavioral; Behavioral Genetics; Body Weights and Measures; CRH gene; Candidate Disease Gene; Characteristics; Collection; Computer Retrieval of Information on Scientific Projects Database; Data; Disease; Eating Disorders; Environment; Environmental Risk Factor; Ethics; Funding; Genes; Genetic; Genetic Polymorphism; Glucose; Goals; Grant; Height; Heritability; Hormones; Hydrocortisone; Individual; Individual Differences; Institution; Insulin; Leptin; Life; Macaca mulatta; Measures; Mental Depression; Mental disorders; Modeling; Oxytocin; Pathology; Physiological; Population; Research; Research Personnel; Resources; Risk; Sampling; Serum; Source; Thyroxine; Triiodothyronine; United States National Institutes of Health; Vasopressins; addiction; adverse outcome; behavior measurement; biobehavior; genetic analysis; monoamine; social group; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Significant progress was made during the current funding period on the completion of this study. Socio-environmental factors significantly affect the risk for developing a number of behavioral and psychiatric disorders in people, including anxiety, depression, eating disorders, and addiction. It is becoming increasingly clear that some individuals are more susceptible to developing these pathologies and that this increased risk may be attributed to genetic factors. While identifying genetic/environment influences on behavior presents practical challenges and ethical constraints in people, rhesus monkeys represent an ideal model to begin to identify the genetic contribution to such disorders. The goal of this project is to conduct an analysis of the genetic heritabilities of a number of biobehavioral and physiological traits that are relevant for psychiatric disorders, followed by linkage and association analysis of candidate genes and gene polymorphisms that account for individual differences in these characteristics using the pedigreed rhesus monkey population living in large social groups at the Field Station. In the past year we completed the collection of the behavioral and physiological samples on the animals. These data included behavioral measures of sociality and aggression, anthropometric measures of body weight, height, BMI, and serum hormone measures of leptin, insulin, triiodothyronine, thyroxin, glucose, and cortisol; and CSF measures of monoamines, CRH, vasopressin, cortisol, and oxytocin. As of Jan 2010, we are awaiting the final results of the CSF analyzes at which point we will begin the heritability analyzes. This project represents a unique opportunity to conduct a translational, behavioral genetics study of candidate genes that predispose individuals to the adverse consequences associated with behavioral and psychiatric disorders, including anxiety and depression.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在当前资助期间，本研究的完成取得了重大进展。 社会环境因素显着影响人们罹患多种行为和精神疾病的风险，包括焦虑、抑郁、饮食失调和成瘾。 越来越清楚的是，一些人更容易患上这些病症，并且这种风险增加可能归因于遗传因素。 虽然识别遗传/环境对行为的影响对人类提出了实际挑战和伦理限制，但恒河猴代表了开始识别遗传对此类疾病的影响的理想模型。 该项目的目标是对与精神疾病相关的许多生物行为和生理特征的遗传性进行分析，然后对候选基因和基因多态性进行连锁和关联分析，以解释这些特征的个体差异生活在野外站的大型社会群体中的纯种恒河猴种群。 去年我们完成了动物行为和生理样本的收集。 这些数据包括社交性和攻击性的行为测量，体重、身高、BMI的人体测量，以及瘦素、胰岛素、三碘甲状腺原氨酸、甲状腺素、葡萄糖和皮质醇的血清激素测量；脑脊液中单胺、CRH、加压素、皮质醇和催产素的测量。 截至 2010 年 1 月，我们正在等待 CSF 分析的最终结果，届时我们将开始遗传力分析。 该项目提供了一个独特的机会，可以对候选基因进行转化行为遗传学研究，这些基因使个体容易遭受与行为和精神疾病（包括焦虑和抑郁）相关的不良后果。