NEUROENDOCRINE MEDIATION OF SOCIALLY INDUCED ANOVULATION

社会诱发的无排卵的神经内分泌调节

• 批准号: 8357427
• 负责人: Mark E Wilson
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357427
• 关键词: Adult; Alleles; Animals; Anovulation; Behavioral; Brain region; Data; Diet; Eating; Energy Metabolism; Estradiol; Fatty acid glycerol esters; Feedback; Female; Fiber; Funding; Genes; Genetic Polymorphism; Genotype; Grant; Housing; Individual; Infertility; Intake; Length; Macaca mulatta; Measures; Mediation; Metabolic; Monkeys; National Center for Research Resources; Neurosecretory Systems; Outcome; Positron-Emission Tomography; Primates; Principal Investigator; Psychosocial Stress; Research; Research Infrastructure; Resources; Serotonin; Source; Stress; Testing; United States National Institutes of Health; Variant; Woman; adverse outcome; cost; experience; insight; neuroimaging; promoter; receptor; reproductive; reuptake; social; treatment strategy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Studies were completed assessing the consequences of psychosocial stress, resulting from social subordination, on metabolic, reproductive, and behavioral outcomes in adult female rhesus monkeys. In addition, the contribution of polymorphisms in the gene that encodes the serotonin reuptake transporter (5HTT) was evaluated as studies show individuals with one or both alleles of the short promoter length variant (s-variant) are more vulnerable to the adverse consequences of psychosocial stress than those homozygous for the long promoter length (l/l). During the final year, studies show that the reproductive compromise experienced by subordinate females is due to enhanced estradiol negative feedback inhibition of LH secretion but that this can be alleviated by access to a high caloric diet. Other studies use PET neuroimaging tested the hypotheses that GABAergic receptor subtype A would be diminished in subordinate s-variant females in brain regions associated with stress reactivity. All PET scans were completed in October 2010 and analyses are underway. Additional studies used automated feeders to quantify intake of standard low fat, high fiber monkey chow in socially housed females to better understand the metabolic deficits observed in subordinates. Activity levels, as a surrogate measure of energy expenditure were measured as well. Data indicate that subordinates, regardless of genotype, eat less of this diet than dominant animals but show similar amounts of activity. These studies provide insights into possible treatment strategies for women suffering from stress-induced infertility.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 研究已经完成，评估了社会从属造成的社会心理压力对成年雌性恒河猴的代谢、生殖和行为结果的影响。 此外，对编码血清素再摄取转运蛋白 (5HTT) 的基因多态性的贡献进行了评估，因为研究表明，具有短启动子长度变体（s 变体）的一个或两个等位基因的个体更容易受到心理社会不良后果的影响。比那些长启动子长度（l/l）的纯合子的应激。 在最后一年，研究表明，从属雌性经历的生殖损害是由于雌二醇对 LH 分泌的负反馈抑制增强所致，但这可以通过高热量饮食来缓解。 其他研究使用 PET 神经影像测试了以下假设：在从属 s 变体女性中，与应激反应相关的大脑区域中 GABA 能受体 A 亚型会减少。 所有 PET 扫描均于 2010 年 10 月完成，分析正在进行中。 其他研究使用自动喂食器来量化社会饲养的雌性猴饲料中标准低脂肪、高纤维的摄入量，以更好地了解在下属中观察到的代谢缺陷。 还测量了作为能量消耗替代指标的活动水平。 数据表明，无论基因型如何，从属动物的饮食量都比优势动物少，但活动量相似。这些研究为患有压力性不孕症的女性提供了可能的治疗策略。