NEUROBIOLOGY OF INCREASED VULNERABILITY TO SOCIAL STRESSORS DURING ADOLESCENCE

青少年时期对社会压力的脆弱性增加的神经生物学

• 批准号: 8172443
• 负责人: Mark E Wilson
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172443
• 关键词: Adolescence; Adolescent; Affect; Behavioral; Brain; Cohort Analysis; Computer Retrieval of Information on Scientific Projects Database; Data; Delayed Puberty; Development; Emotional; Enantone; Estradiol; Female; Female Adolescents; Funding; Genes; Genetic Polymorphism; Glucocorticoids; Grant; Housing; Institution; Macaca mulatta; Modeling; Neurobiology; Positron-Emission Tomography; Proteins; Psychosocial Stress; Puberty; Recruitment Activity; Research; Research Personnel; Resources; Serotonin; Source; United States National Institutes of Health; Variant; behavior test; cohort; density; design; neuroimaging; neurotransmission; novel; receptor binding; social; social group; social stress; stressor; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using a rhesus monkey model, this project is designed to provide a better understanding of how psychosocial stress, imposed by social subordination, affects brain maturation and emotional development in females and whether this is influenced by polymorphisms in the gene that encodes the serotonin re-uptake transporter (5HTT), a protein essential for normal serotonin neurotransmission and emotionality. Significant progress was made during the current year on the first cohort of adolescents (n = 37) that are housed in large social groups at the Field Station. Data show that adolescent females are less sensitive to glucocorticoid negative, suggesting they may be particularly vulnerable to the stress of social subordination. Furthermore, subordinate adolescent females with the s-variant polymorphism in the gene encoding the 5HTT are more reactive to novel objects, reflecting greater emotional reactivity. Structural MR, DTI, and PET imaging of 5HTT and 5HT 1A receptor binding density were completed on this cohort and analyses are still in progress. As expected, the more socially dominant females of this cohort have entered puberty whereas the subordinate females have not. The second cohort (n = 39) was recruited this year and they too are housed in the large social groups at the Field Station. This group, however, is being treated with Lupron, to experimentally delay puberty and developmental increases in estradiol. Behavioral testing, glucocorticoid assessments, and neuroimaging have begun on this cohort. These studies will show the importance of estradiol for behavioral and brain maturation during adolescence in females.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 Using a rhesus monkey model, this project is designed to provide a better understanding of how psychosocial stress, imposed by social subordination, affects brain maturation and emotional development in females and whether this is influenced by polymorphisms in the gene that encodes the serotonin re-uptake transporter (5HTT), a protein essential for normal serotonin neurotransmission and emotionality. 在本年度，在最初的青少年队列（n = 37）中取得了重大进展，这些群体位于大型社会群体中。 数据表明，青春期女性对糖皮质激素的阴性不太敏感，这表明她们可能特别容易受到社会从属压力的影响。 此外，编码5HTT的基因中具有S变量多态性的下属女性对新物体更具反应性，反映了更大的情感反应性。 在该队列上完成了5HTT和5HT 1A受体结合密度的结构MR，DTI和PET成像，并且仍在进行分析。 正如预期的那样，该队列的社会占主导地位的女性进入了青春期，而下属女性则没有。 第二个队列（n = 39）是今年招募的，它们也位于现场站的大型社会团体中。 然而，该组正在用卢普拉（Lupron）进行治疗，以实验延迟雌二醇的青春期和发育增加。 行为测试，糖皮质激素评估和神经影像学已经开始在该队列上。 这些研究将表明雌二醇对女性青春期期间行为和脑成熟的重要性。