Developmental Activities

发展活动

• 批准号: 7983702
• 负责人: ROBERT Samuel LANGER
• 金额: $ 8.25万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7983702
• 关键词: Advisory Committees; CCNE1 gene; Cells; Chad; Clinical; Collaborations; Communication; Communities; Consultations; DNA; Data; Databases; Deposition; Development; Direct Costs; Disseminated Malignant Neoplasm; Education and Outreach; Educational process of instructing; Evaluation; Exhibits; Faculty; Festival; Funding; General Population; Genes; Goals; Gold; Grant; Hybrids; Image; Magnetic Resonance Imaging; Mails; Microfluidics; Mission; Mus; Museums; Nanotechnology; Nucleic Acids; Pilot Projects; Public Domains; Publications; Research; Research Personnel; Research Project Grants; Resources; Schools; Science; Series; Sorting - Cell Movement; Staging; Students; Vision; Visit; Work; base; cancer Biomedical Informatics Grid; career; clinically relevant; data sharing; design; di-block copolymer; flexibility; high school; in vivo; interest; lectures; member; mouse model; nano; nanomaterials; nanomedicine; nanoparticle; neoplastic cell; outreach; programs; public education; tumor; web site

OVERALL VISION FOR DEVELOPMENTAL ACTIVITIES Over the last 5 years of our CCNE, there has been a tremendous interest by researchers to join the consortium through pilot projects and/or collaborative research. We view such projects as an important adjunct of the CCNE's mission and from which full projects and important science can emerge. For example, in the past our consortium has funded the selected following projects: ¿ Paula Hammond and Dane Wittrup (pilot project) on functionalized linear-dendritic diblock copolymers for tumor-selective nucleic acid delivery. One ofthe postdocs (Greg Thurber) now works in the Weissleder lab and confinues interactions (85, 86) ¿ Stephen Lippard (pilot project) on functionalizing gold nanoparticles with DNA duplexes containing tethered, releasable plafinum conjugates at their termini in collaboration with Chad Mirkin at Northwestern CCNE (87) ¿ Robert Westen/elt (pilot project) on hybrid integrated circuit/microfluidic chips forthe manipulation of cells (88, 89) ¿ Sridhar Ramaswamy (pilot project) on nanomodels of metastatic cancer (90) ¿ Mehmet Toner and Daniel Haber (pilot project) on microfluidic sorting of circulating tumor cells. This original pilot project has resulted in several high impact publications (91-93) and funding outside the consortium, including a recent SU2C grant involving several CCNE members (Bhatia, Weissleder). Pilot, Alliance Challenge and other exploratory projects provide a mechanism by which to attract new researchers and to rapidly fund the most promising ideas. The following section lists some of our general plans on continuing developmental activities.

发展活动的整体愿景 在我们CCNE的最后5年中，研究人员非常有兴趣通过试点项目和/或协作研究加入财团。我们将这些项目视为CCNE使命的重要辅助，并且可以从中出现完整的项目和重要的科学。例如，过去，我们的财团资助了以下项目： Paula Hammond和Dane Wittrup（试点项目）在功能化线性树枝状二嵌段共聚物上用于肿瘤选择性核酸的递送。现在，其中一个博士后（格雷格·瑟伯（Greg Thurber））在魏斯德尔实验室（Weissleder Lab）工作，并确认相互作用（85，86） �StephenLippard（试点项目）关于用含有DNA双链体功能功能化金纳米颗粒 与乍得·米尔金（Chad Mirkin）合作，在他们的终点站上绑住，可释放的plafinum con轭 西北CCNE（87） „混合综合电路/微流体芯片的Robert Westen/ELT（试点项目）用于操纵 细胞（88，89） „转移性癌症纳米模型的Sridhar Ramaswamy（试点项目）（90） „ Mehmet Toner和Daniel Haber（试点项目）关于循环肿瘤细胞的微流体分类。这 原始飞行员项目导致了一些高影响力出版物（91-93），并在外面进行了资金 财团，包括最近的SU2C赠款，涉及几名CCNE成员（Bhatia，Weissleder）。 飞行员，联盟挑战和其他探索项目提供了一种吸引新的机制 研究人员并迅速为最有前途的想法提供资金。以下部分列出了我们有关持续发展活动的一些一般计划。