Alliance Challenge Projects

联盟挑战项目

• 批准号: 7983260
• 负责人: SANJIV S GAMBHIR
• 金额: $ 9.46万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7983260
• 关键词: Area; Arvin; Biomedical Engineering; Chemistry; Clinical; Collaborations; Commit; Committee Members; Communities; Development; Developmental Biology; Diagnostic; Discipline; Engineering; Environment; Evaluation; Faculty; Fostering; Funding; Goals; Humanities; In Vitro; Institution; Investments; Letters; Malignant Neoplasms; Medicine; Molecular; Nanotechnology; Operative Surgical Procedures; Pharmacology; Physics; Pilot Projects; Process; Radiology Specialty; Research; Research Infrastructure; Research Personnel; Research Proposals; Resources; Running; Science; Scientist; Universities; cancer Biomedical Informatics Grid; computer science; cost; experience; fight against; interdisciplinary approach; medical schools; meetings; member; multidisciplinary; nano; programs; skills; square foot; success; tool; working group

N6. Developmental Activities (Plans for Pilot Projects, Alliance Challenge Projects, and Other Trans-Alliance Activities). A summary of key scientific and translational capabilities that our CCNE-T can provide in support of Developmental Activities is given next. The proposed CCNE-T is more than capable of developing and sustaining the various Developmental Activities for the following four-fold reasons: 1) Experience: We have been successfully running CCNE-TR sponsored Developmental (Pilot) Projects in our existing Center since 2006 until now, thus, we have already accumulated significant know-how and experience regarding how to initiate and maintain these types of Developmental Projects. Our Center administration team and the Executive Committee (EC) members are highly skilled in this regard. Leveraging on this accumulated experience and skills, we plan to continue these proven-successful processes for selection, evaluation and initiation of these Pilot Projects. 2) Environment: The research and educational environments both at Stanford, and also at our collaborating partner institutions, are exceptionally good and readily available. Highly specialized expertise in both the cancer and nanotechnology arenas can be harnessed that is of outstanding quality, therefore, we expect to continue seeing great enthusiasm from the various research groups on campus to be part of the Center. This appeal has been leading directly into the funding of 3-4 Pilot Projects per year. We typically receive >15 pre-proposal submissions in each year. 3) Investment: Stanford University has made significant investments in several key areas that directly impact this research proposal. For a decade now, Stanford University has strongly believed that its strengths in the Schools of Medicine, Engineering, and Humanities & Sciences need to be leveraged towards advancing Biomedical Sciences. It is for this reason that President Hennessey, the Deans of Medicine (Pizzo), Engineering (Plummer), and of Humanities and Sciences (Sailer) are all enthusiastic supporters of this proposal (see Letters of Support at the end of this section). As part of the institutional commitment to this interdisciplinary approach to the Biosciences, a key effort known as the Bio-X Program was established and a new building of 225,000 square feet known as the James H. Clark Center was constructed. This was an investment of over $175 million in construction costs and infrastructure that brings together scientists from many disciplines including Chemistry, Applied Physics, Bioengineering, Computer Science, Developmental Biology, Molecular Pharmacology, Medicine, Surgery, and Radiology. All the Bio-X Program Scientists share a common goal to advance Biomedical Science. This proposal will tremendously benefit from the environment at Stanford and the Bio-X that fosters highly multidisciplinary efforts. Dr. Carla Shatz (lAB of CCNE-T) who is the Director of the Bio-X Program, and Dr. Ann Arvin (lAB of CCNE-T) who is the Vice Provost and Dean of Research overseeing the Bio-X Program, are highly supportive of this proposal as it is the exact type of collaborative effort that the Bio-X would like to foster (see lAB Support Letters). These Stanford committed resources, from new infrastructure expansion and support of new faculty billets for nanotechnology and cancer, will provide outstanding support and major enablers for success in multidisciplinary efforts such as the existing CCNE-TR and the newly proposed continuation center CCNE-T. 4) Investigator Activity: Our investigators are highly active in the cancer nanotechnology community. For example, Dr. Sam Gambhir serves as a Scientific Advisory Board Member to NCI; Dr. David Paik is currently one ofthe leaders in the NCI Alliance's caNano Lab and caBIG programs; and Dr. Shan Wang organizes the Alliance's in vitro Diagnostics Working Group and also serves as the Chair of the relevant NCI Cancer Nano Alliance investigator meeting. Most of our investigators have already interacted with other CCNEs and CNPPs (Cancer Nanotechnology Partnership Programs) as indicated in Appendix 13 and in section N1.4.10. We will continue our efforts to increase collaborations and also to accelerate the realization of our promising cancer nanotechnology tools as clinical aids in the fight against cancer. We strongly believe that for all of the reasons as outlined above, we can guarantee the continuation, new formation, and progression of our Developmental Activities, Alliance Challenge Projects, and other Alliance Activities. We plan to accomplish these activities as described in the following sections.

N6。发展活动（试点项目，联盟挑战项目和其他跨合同活动的计划）。 接下来，将对我们的CCNE-T可以提供支持发展活动的关键科学和翻译能力的摘要。拟议的CCNE-T由于以下四个原因而有能力开发和维持各种发展活动：1）经验：自2006年以来，我们一直在我们现有中心成功运行CCNE-TR赞助的发展（PILOT）项目，直到现在为止，因此，我们已经积累了有关如何启动和维护这些类型的开发项目的大量专有技术和经验。我们的中心管理团队和 执行委员会（EC）成员在这方面非常熟练。利用这些积累的经验和技能，我们计划继续这些熟练的过程，以选择，评估和启动这些试点项目。 2）环境：斯坦福大学的研究和教育环境以及我们的合作伙伴机构的研究和教育环境非常好，很容易获得。在癌症和纳米技术领域的高度专业知识都可以利用出色的质量，因此，我们希望继续看到各种研究的热情 校园的团体成为中心的一部分。这项上诉一直直接领导每年3-4个试点项目的资金。通常，我们每年都会收到> 15次预言意见。 3）投资：斯坦福大学在直接影响该研究建议的几个关键领域进行了大量投资。十年来，斯坦福大学一直坚信，它在医学，工程和人文学科和人文和科学学校中的优势需要利用来推进生物医学科学。出于这个原因，轩尼诗总统，医学院长（Pizzo），工程（Plummer）以及人文和科学（Sailer）都是该建议的热情支持者（请参阅 本节末尾的支持信）。作为对生物科学的这种跨学科方法的机构承诺的一部分，建立了一个称为Bio-X计划的关键努力，并建立了一座新建筑225,000平方英尺，称为James H. Clark Center。这是一项超过1.75亿美元的建筑成本和基础设施的投资，汇集了许多学科的科学家，包括化学，应用物理学，生物工程，计算机科学，发展生物学，分子 药理学，医学，手术和放射学。所有BIO-X计划科学家都有一个共同的目标来推进生物医学科学。该提议将从斯坦福大学和促进高度多学科努力的BIO-X环境中受益匪浅。 BIO-X计划的主任Carla Shatz（CCNE-T的实验室）和Ann Arvin博士（CCNE-T的实验室）是副教务长和研究BIO-X计划的副院长，对该建议非常支持此提案，因为这是确切的合作努力类型的合作类型。 Bio-X希望养育（请参阅实验室支持信）。这些斯坦福大学提供的资源是从新的基础设施扩展以及对纳米技术和癌症的新教师方形的支持，将为跨学科工作的成功提供出色的支持和主要支持者，例如现有的CCNE-TR和新提出的新提议的延续中心CCNE-T。 4）研究人员活动：我们的研究人员在癌症纳米技术社区中高度活跃。例如，Sam Gambhir博士是NCI的科学顾问委员会成员； David Paik博士目前是NCI联盟Canano实验室的领导者之一 和Cabig计划； Shan Wang博士组织了联盟的体外诊断工作组，并担任相关NCI癌症纳米联盟研究员会议的主席。我们的大多数调查人员已经与附录13和N1.4.10节中所示的其他CCNES和CNPP（癌症纳米技术合作计划）进行了互动。我们将继续努力提高合作，并加速我们有前途的癌症纳米技术工具作为战斗中的临床辅助工具 反对癌症。我们坚信，出于上述所有概述的所有原因，我们可以保证我们的发展活动，联盟挑战项目和其他联盟活动的延续，新的形成和发展。我们计划按照以下各节所述完成这些活动。