Vevo LAZR Photoacoustic and Ultrasound Imaging System

Vevo LAZR 光声和超声成像系统

• 批准号: 8447766
• 负责人: SANJIV S GAMBHIR
• 金额: $ 52.19万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-18 至 2014-06-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8447766
• 关键词: Acoustics; Animals; Applications Grants; Area; Basic Science; Biology; Biomedical Research; Cardiovascular Diseases; Cardiovascular system; Cerebral Neoplasm; Clinical; Communities; Contrast Media; Development; Diagnostic radiologic examination; Disease; Early Diagnosis; Frequencies; Goals; Gold; Health; Hemoglobin; Human; Image; Investigation; Laboratories; Melanins; Mission; Molecular; Molecular Probes; Neoplasm Metastasis; Optics; Patient Care; Patients; Public Health; Research; Resolution; Staging; System; Technology; Therapy Evaluation; Time; Ultrasonography; Universities; Visual; acoustic imaging; deoxyhemoglobin; imaging modality; imaging probe; insight; instrumentation; molecular imaging; multimodality; myocardial hypoxia; nanoparticle; photoacoustic imaging; single walled carbon nanotube; translational study; tumor microenvironment; Acoustics; Animals; Applications Grants; Area; Basic Science; Biology; Biomedical Research; Cardiovascular Diseases; Cardiovascular system; Cerebral Neoplasm; Clinical; Communities; Contrast Media; Development; Diagnostic radiologic examination; Disease; Early Diagnosis; Frequencies; Goals; Gold; Health; Hemoglobin; Human; Image; Investigation; Laboratories; Melanins; Mission; Molecular; Molecular Probes; Neoplasm Metastasis; Optics; Patient Care; Patients; Public Health; Research; Resolution; Staging; System; Technology; Therapy Evaluation; Time; Ultrasonography; Universities; Visual; acoustic imaging; deoxyhemoglobin; imaging modality; imaging probe; insight; instrumentation; molecular imaging; multimodality; myocardial hypoxia; nanoparticle; photoacoustic imaging; single walled carbon nanotube; translational study; tumor microenvironment

DESCRIPTION (provided by applicant): The aim of this Shared Instrumentation Grant application is the acquisition of an upgrade of a Visual Sonics Vevo(R) 2100, to Vevo(R) LAZR Photo acoustic and Ultrasound Imaging System, allowing for the totally new imaging modality to be made available. This upgrade will have an enormous impact on the many projects, both basic science and translational, across Stanford University's diverse research community. The existing Vevo(R) 2100, a high frequency ultrasound, offers users the ability to view internal anatomical features with high spatial resolution. The proposed upgrade will allow photo acoustic imaging by contributing optical contrast, enabling real-time images possessing anatomical, functional and molecular information, extremely important for better understanding of underlying biology and for successful translational studies. Major research applications of the Vevo(R) photo acoustic technology are envisioned to be in the areas of oncological, cardiovascular and neuro- imaging. This technology allows imaging of both endogenous (hemoglobin, deoxyhemoglobin, melanin) and exogenous contrast agents and molecular probes (single walled carbon nanotubes, gold nanoparticles etc.) and as such will provide for our research community a unique insight into diverse studies, including investigations of the tumor microenvironment, metastases, cerebral and tumor hypoxia, and myocardial strain. In the long run, we believe these studies will have a profound impact on early detection of a range of disorders as well as on the improvement of various areas of patient care such as staging, therapy evaluation and overall patient management. Since clinical photo acoustic systems are under development by several groups, the small animal studies described herein are highly relevant to public health and support not only the biomedical research goals set at Stanford University but align well with NIH's mission of advancing human health through fundamental scientific discoveries. The investigations will take place at interdisciplinary laboratories directd by recognized leaders in biomedical research: multimodality molecular imaging (Dr. Sanjiv Sam Gambhir), molecular imaging probe development (Drs. Jianghong Rao and Zhen Cheng), cardiovascular disease (Drs. Euan Ashley, Joseph Wu and Ching-Pin Chang), and diagnostic radiology (Drs. Juergen Willmann, Amelie Lutz and Aya Kamaya).

描述（由申请人提供）：此共享仪器授予应用程序的目的是获取视觉超音速VEVO（R）2100的升级，升级到Vevo（R）LAZR照片声学和超声成像系统，允许提供全新的成像方式。该升级将对斯坦福大学多元化研究社区的许多基础科学和翻译的许多项目产生巨大影响。现有的VEVO（R）2100是高频超声波，使用户能够查看具有高空间分辨率的内部解剖特征。拟议的升级将通过构成光学对比度，实现具有解剖学，功能和分子信息的实时图像来允许照片声学成像，对于更好地理解潜在的生物学和成功的翻译研究极为重要。 VEVO（R）照片声学技术的主要研究应用是在肿瘤，心血管和神经成像的领域。 This technology allows imaging of both endogenous (hemoglobin, deoxyhemoglobin, melanin) and exogenous contrast agents and molecular probes (single walled carbon nanotubes, gold nanoparticles etc.) and as such will provide for our research community a unique insight into diverse studies, including investigations of the tumor microenvironment, metastases, cerebral and tumor hypoxia, and myocardial 拉紧。从长远来看，我们认为这些研究将对早期发现一系列疾病以及改善患者护理的各个领域（例如分期，治疗评估和整体患者管理）产生深远影响。由于几个小组正在开发临床照片声学系统，因此本文所述的小动物研究与公共卫生高度相关，不仅支持斯坦福大学设定的生物医学研究目标，而且还与NIH通过基本科学发现促进人类健康的使命相吻合。这项研究将在跨学科实验室进行直接由公认的生物医学研究领导者进行：多模式分子成像（Sanjiv Sam Gambhir博士），分子成像探针开发（Jianghong Rao和Zhen Cheng博士），心血管疾病，Drs euan Ashley，euan Ashley，jose and jose and jose and jange and chings and chings and chings and drast and drast and drast and-drast and-drast and-drast and-drast and-drast。 Juergen Willmann，Amelie Lutz和Aya Kamaya）。