Center for Cancer Nanotechnology Excellence and Translation (CCNE-T)

癌症纳米技术卓越与转化中心 (CCNE-T)

• 批准号: 8540368
• 负责人: SANJIV S GAMBHIR
• 金额: $ 233.45万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-26 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8540368
• 关键词: Aftercare; Animal Model; Area; Biochemical Pathway; Biological Markers; Biopsy; Blood; Blood Proteins; Blood Tests; California; Cancer Biology; Cancer Center; Cancer Patient; Cell Separation; Cells; Chemistry; Clinical; Clinical Trials; Communities; Devices; Diagnostic; Diagnostic Neoplasm Staging; Early Diagnosis; Early Intervention; Early treatment; Engineering; Ensure; Five-Year Plans; Foundations; Funding; Future; Goals; Grant; Heterogeneity; Image; Imaging technology; In Vitro; Individual; Institutes; Link; Location; Los Angeles; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of ovary; Massachusetts; Measures; Methods; Molecular Biology Techniques; Monitor; Nanotechnology; National Cancer Institute; Neoplasm Circulating Cells; Outcome; Ovarian; Patients; Phosphotransferases; Physicians; Positron-Emission Tomography; Protein Engineering; Proteins; Proteomics; Regimen; Research Project Grants; Research Proposals; Resources; Sampling; Science; Scientist; Screening for Ovarian Cancer; Screening for cancer; Serinus; Signal Transduction; Site; Staging; Survival Rate; TNFRSF5 gene; Technology; Testing; Therapeutic; Therapeutic Intervention; Time; Translating; Translations; Tumor Burden; Universities; Validation; Vision; anticancer research; base; cancer diagnosis; cancer therapy; cost; improved; in vivo; in vivo Cellular and Molecular Imaging Centers; innovation; mathematical model; meter; molecular imaging; multidisciplinary; nano; nanofabrication; nanoparticle; nanoscience; nanosensors; nanosystems; next generation; novel; oncology; outreach; physical science; programs; response; tumor

DESCRIPTION (provided by applicant): This Center for Cancer Nanotechnology Excellence and Translation (CCNE-T) brings together scientists and physicians from Stanford University, University of California Berkeley/Lawrence Berkeley National Lab, University of California Los Angeles, University of Southern California and the Massachusetts Institute of Technology. The grant also leverages on several activities in cancer biomarker discovery/validation with the Canary Foundation and the Fred Hutchinson Cancer Center. This research proposal is centered around our vision that in vitro diagnostics used in conjunction with in vivo diagnostics can markedly impact future cancer patient management. Furthermore, we believe that nanotechnology can significantly advance both in vitro diagnostics through proteomic nanosensors and in vivo diagnostics through nanoparticles for molecular imaging. The cancer-related biochemical pathways targeted will be the Her kinase axis with a focus on predicting and monitoring response to lung cancer therapy. An additional focus will be on the earlier detection of Ovarian Cancer. We have assembled a highly interdisciplinary team of scientists from the fields of chemistry, materials science and engineering, molecular imaging, oncology, cancer biology, protein engineering, and mathematical modeling in order to accomplish our goals. We highly leverage resources at the Stanford Bio-X and Nanoscale Science and Engineering Programs, the California Nanosystems Institute, and the Cancer Centers of Stanford/UCL/VUSC/Fred Hutchinson. We will utilize significant resources at several small companies we have started and General Electric. We have direct links to a Fred Hutchinson Ovarian SPORE, a recently funded Physical Sciences Oncology Center (PSOC), the ICMIC P50, ICBP, and NTR at Stanford. Furthermore, the Canary Foundation will provide more than $3M towards clinical trials to translate our nanotechnologies and help with outreach. Four research projects and three cores are proposed. Project #1 focuses on novel smart nanoparticles including Raman and self-assembling nanoparticles, Project #2 focuses on the use of magneto-nanotechnology for blood proteomics and cell sorting. Project #3 focuses on the use of multiple nano-platforms to interrogate single circulating tumor cells. Project #4 focuses on molecular imaging of ovarian cancer with photoacoustics and Raman nanoparticles, and monitoring response to therapy using imaging and magneto-nanosensors. Core #1 will facilitate Nanoinformatics, Core #2 will provide resources for nanocharacterization and nanofabrication, Core #3 will facilitate clinical translation by linking our nanotechnologies to existing patient samples and ongoing as well as new clinical trials. With our highly interactive and cohesive program focused on developing and validating nanotechnology for anti-cancer therapy response and earlier cancer detection, we will imagine, invent, and innovate for the benefit of cancer patients.

描述（由申请人提供）：该癌症纳米技术卓越与转化中心 (CCNE-T) 汇集了来自斯坦福大学、加州大学伯克利分校/劳伦斯伯克利国家实验室、加州大学洛杉矶分校、南加州大学和麻省理工学院。该赠款还利用了金丝雀基金会和 Fred Hutchinson 癌症中心在癌症生物标志物发现/验证方面的多项活动。这项研究提案的核心是我们的愿景，即体外诊断与体内诊断结合使用可以显着影响未来的癌症患者管理。此外，我们相信纳米技术可以显着推进通过蛋白质组纳米传感器的体外诊断和通过分子成像纳米颗粒的体内诊断。与癌症相关的生化途径的目标将是 Her 激酶轴，重点是预测和监测对肺癌治疗的反应。另外一个重点将是卵巢癌的早期检测。为了实现我们的目标，我们组建了一支由来自化学、材料科学与工程、分子成像、肿瘤学、癌症生物学、蛋白质工程和数学建模领域的高度跨学科的科学家组成的团队。我们高度利用斯坦福 Bio-X 和纳米科学与工程项目、加州纳米系统研究所以及斯坦福/伦敦大学学院/弗吉尼亚州立大学/弗雷德·哈钦森癌症中心的资源。我们将利用我们已经创办的几家小公司和通用电气的大量资源。我们与 Fred Hutchinson 卵巢 SPORE、最近资助的物理科学肿瘤中心 (PSOC)、斯坦福大学的 ICMIC P50、ICBP 和 NTR 有直接联系。此外，金丝雀基金会将提供超过 300 万美元用于临床试验，以转化我们的纳米技术并帮助推广。提出了四个研究项目和三个核心。项目#1专注于新型智能纳米颗粒，包括拉曼和自组装纳米颗粒，项目#2专注于利用磁纳米技术进行血液蛋白质组学和细胞分选。项目#3 侧重于使用多个纳米平台来询问单个循环肿瘤细胞。项目#4 专注于利用光声和拉曼纳米颗粒对卵巢癌进行分子成像，并利用成像和磁纳米传感器监测治疗反应。核心#1将促进纳米信息学，核心#2将为纳米表征和纳米制造提供资源，核心#3将通过将我们的纳米技术与现有患者样本以及正在进行的和新的临床试验联系起来，促进临床转化。通过我们高度互动和有凝聚力的项目，专注于开发和验证用于抗癌治疗反应和早期癌症检测的纳米技术，我们将为了癌症患者的利益而想象、发明和创新。