SLEEP AND ABNORMAL BEHAVIOR

睡眠和异常行为

• 批准号: 7349323
• 负责人: GENE P. SACKETT
• 金额: $ 13.2万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349323
• 关键词: SLEEP; ABNORMAL; BEHAVIOR

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Captive macaque monkeys housed for long periods of time in single cages often develop behaviors that are atypical for their species and may indicate disturbance and abnormality. A common atypical behavior is stereotyped repetitive locomotion. A less common (3-5%) behavior type is potential or actual self-injurious behaviors (SIBs). SIBs include actions such as self-biting, chronic hair pulling or grooming, and head banging. SIB may occur daily or much less frequently in different animals, and is often resistant to treatment. This study tested the hypothesis that SIB is correlated with disturbed sleep. Eight pairs of aged adult monkeys (m. fascicularis) included one animal that exhibited daytime SIB and one not seen to exhibit SIB during daytime hours. Movement during night (room dark) hours was detected by an infrared video system, which activated computer digital video recording for the duration of movement. Amount of activity was automatically recorded and video scenes were scored by observers for the type of activity. Overall, SIB monkeys had more night wake periods for longer durations than controls. SIB monkeys often exhibited their SIB behavior during active periods. Of most importance for identifying animals with SIB, one control monkey, never observed to self-bite, exhibited the most self-biting during the night. Sleep observations are currently being followed in infant and juvenile monkeys to determine relationships between night period activity and daytime behavior and cortisol.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。长期圈养在单个笼子里的猕猴经常会出现对其物种来说非典型的行为，可能表明存在干扰和异常。一种常见的非典型行为是刻板的重复运动。一种不太常见 (3-5%) 的行为类型是潜在或实际的自残行为 (SIB)。 SIB 包括自咬、长期拉扯或梳理头发以及撞头等行为。在不同的动物中，SIB 可能每天都会发生，或者发生的频率要低得多，并且通常对治疗有抵抗力。这项研究检验了 SIB 与睡眠障碍相关的假设。八对老年成年猴子 (m. fascicularis) 包括一只在白天表现出 SIB 的动物和一只在白天未表现出 SIB 的动物。红外视频系统检测到夜间（房间黑暗）期间的运动，该系统在运动期间激活计算机数字视频记录。自动记录活动量，并由观察者根据活动类型对视频场景进行评分。总体而言，SIB 猴比对照组有更多的夜间清醒时间，持续时间更长。 SIB 猴经常在活跃期表现出 SIB 行为。对于识别患有 SIB 的动物来说，最重要的是，一只从未观察到自咬的对照猴子在夜间表现出最多的自咬行为。目前正在对婴儿和幼年猴子进行睡眠观察，以确定夜间活动与白天行为和皮质醇之间的关系。