Center for Integration of Research on Genetics and Ethics

遗传学与伦理学研究整合中心

基本信息

批准号：
7848439
负责人：
Mildred K. Cho
金额：
$ 109.82万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-01 至 2015-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7848439
关键词：
Achievement Acute Address Altruism Area Basic Science Behavior Behavioral Characteristics Clinical Cognitive Communities Complex Consultations Development Diagnostic Discrimination Disease Education Employment Environment Ethics Ethics Consultation Eugenics Feedback Funding Future Gap Junctions Genealogy General Population Genetic Genetic Research Genetic Risk Genetic screening method Genome Genomics Goals Growth Health Health Policy Human Image Individual Institution Laws Legal Link Maps Medical Medicine Morals Movement National Human Genome Research Institute Parenting behavior Patients Personality Traits Play Policies Policy Maker Policy Research Principal Investigator Process Public Policy Recording of previous events Reproduction Research Research Personnel Research Project Grants Risk-Taking Role Science Scientist Services Shapes Social Behavior Social Environment Social Policies Stigmata Technology Technology Assessment Training Training Programs Translating Translational Research Translations Universities Vision Voting anti social base behavioral genomics design ethical legal social implication falls genome sequencing innovation interest normative feedback novel strategies pleiotropism pre-doctoral prognostic programs research and development social social stigma trait

项目摘要

DESCRIPTION (provided by applicant): The Center for Integration of Research on Genetics and Ethics (CIRGE) was established in 2004. The overall goal of CIRGE is the proactive identification and integration of ethical, legal and social considerations into the design and conduct of current and emerging genetic research. Our thematic focus is on genomics of behavioral traits. The aims of CIRGE in this renewal application are to: 1) Conduct interdisciplinary ELSI research that informs policy regarding the conduct and translation of research on the genomics of behavior; 2) Develop an anticipatory approach to integrate ethics, policy and research on the genomics of behavior by linking the process of research on the genomics of behavior with the ELSI research and policy agendas; and 3) Train interdisciplinary ELSI researchers who are fluent in genomics, ethics and policy. CIRGE will serve as a nexus between stakeholders and end-users of the research on the genomics of behavior, genome scientists, and the ELSI research community. We will create a forum for integrating ethical and social considerations into specific areas of genomic research through: 1) "prognostic" normative analyses that identify the values, principles and assumptions implicated by research, technology and their applications, 2) empirical analyses to map relevant genomic research and technology and identify stakeholders, 3) empirical analyses to assess relevant features of the ethical, legal or social context, such as how different stakeholders think genome information or technology will be used, should be used, is perceived, or who it might benefit or harm, 4) "diagnostic" normative analyses to assess whether and how genomic research and technology supports or undermines stakeholder values, and 5) feedback of normative and empirical ELSI findings into research and development priorities, design criteria or other requirements. These processes can inform the design and application of genome research to enhance benefit and utility to end-users and facilitate translation to clinical and non-medical uses. CIRGE's innovation will be in developing a process for coordinating ELSI research agendas around specific focus areas in genomic research, and for translating the ELSI research findings into design features of genomic research and technology. RELEVANCE: CIRGE's aims to facilitate the appropriate and ethical translation of research on the genomics of behavior in a way that serves the needs and values of end users and stakeholders, including patients, clinicians, and health policy makers.

描述（由申请人提供）：2004年成立了遗传和道德研究（CIRGE）的整合中心。CIRGE的总体目标是将道德，法律和社会考虑在当前的设计和行为中积极识别和整合到当前的设计和行为和新兴的遗传研究。我们的主题重点是行为特征的基因组学。 CIRGE在此续签应用中的目的是：1）进行跨学科的ELSI研究，以指导有关行为基因组学研究的行为和翻译的政策； 2）通过将有关行为基因组基因组基因组研究的过程与ELSI研究和政策议程联系起来，开发一种对行为基因组基因组基因组学的伦理，政策和研究的预期方法； 3）训练流利的基因组，伦理和政策的跨学科ELSI研究人员。 CIRGE将在利益相关者和有关行为基因组，基因组科学家和ELSI研究社区的研究研究者的最终用户之间充当联系。我们将创建一个论坛，将道德和社会考虑因素整合到基因组研究的特定领域中：1）“预后”规范性分析，以确定研究，技术及其应用所涉及的价值，原理和假设，2）经验分析以绘制相关的相关性分析基因组研究和技术并确定利益相关者，3）经验分析，以评估道德，法律或社会背景的相关特征，例如不同的利益相关者如何使用，应使用，可感知的基因组信息或技术，或者可能是谁受益或伤害，4）“诊断”规范性分析，以评估基因组研究和技术如何支持或破坏利益相关者的价值，以及5）对研究和发展优先级，设计标准或其他要求的规范和经验性ELSI发现的反馈。这些过程可以为基因组研究的设计和应用提供信息，以增强最终用户的利益和效用，并促进转化为临床和非医疗用途。 Cirge的创新将是开发一个过程，以协调基因组研究中特定重点领域的ELSI研究议程，并将ELSI研究结果转化为基因组研究和技术的设计特征。相关性：Cirge的目的是促进对行为基因组基因组学研究的适当和道德翻译，以满足最终用户和利益相关者的需求和价值的方式，包括患者，临床医生和卫生决策者。