GENETIC MANAGEMENT OF ANIMAL COLONIES

动物群体的遗传管理

• 批准号: 8172544
• 负责人: DAVID Glenn SMITH
• 金额: $ 7.6万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172544
• 关键词: Candidate Disease Gene; Computer Retrieval of Information on Scientific Projects Database; Funding; Genetic; Genome; Genotype; Grant; Institution; Macaca; Macaca mulatta; Population; Research; Research Personnel; Resources; Services; Single Nucleotide Polymorphism; Source; United States National Institutes of Health; animal colony; base; disease phenotype; genome wide association study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this project are to 1) identify single nucleotide polymorphisms (SNPs) useful to genetically characterize genetic differences within and among regional populations of rhesus and longtail macaques, 2) identify a panel of SNPs most useful for genetic management, and 3) provide genotyping and genetic management services to NIH investigators based on high throughput genotyping of the SNP panel using the UCD Genome Center. This project will also identify an expanded panel of highly polymorphic SNPs for use in whole genome association studies to detect candidate genes for specific diseases and phenotypes.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的目标是 1) 确定单核苷酸多态性 (SNP)，可用于从遗传角度表征恒河猴和长尾猕猴区域种群内部和之间的遗传差异，2) 确定一组对遗传管理最有用的 SNP，以及 3) 提供基于使用 UCD 基因组中心对 SNP 组进行高通量基因分型，为 NIH 研究人员提供基因分型和遗传管理服务。该项目还将确定一组扩展的高度多态性 SNP，用于全基因组关联研究，以检测特定疾病和表型的候选基因。