LIPOPROTEIN AND HYPERTENSION QTL CANDIDATE GENES

脂蛋白和高血压 QTL 候选基因

• 批准号: 8172708
• 负责人: Laura A Cox
• 金额: $ 15.46万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172708
• 关键词: Binding; Candidate Disease Gene; Computer Retrieval of Information on Scientific Projects Database; Dyslipidemias; Funding; Genes; Goals; Grant; High Density Lipoprotein Cholesterol; Hypertension; Institution; Lipase; Lipoproteins; Liver; Modeling; Molecular; Papio; Phenotype; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Variant; oxidative damage; promoter; transcription factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of Project 3 is to identify genes that influence quantitative phenotypes related to dyslipidemia, oxidative damage and hypertension in the baboon model. We are currently studying molecular mechanisms by which variation in endothelial lipase influences variation in high density lipoprotein cholesterol (HDLC). We have identified functional variants in the endothelial lipase gene promoter that influence HDLC. In addition, we have identified transcription factors that differentially bind to one of these functional variants and quantified expression of the transcription factors in baboon liver, demonstrating differences between low and high HDLC baboons.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 项目 3 的目标是确定影响狒狒模型中血脂异常、氧化损伤和高血压相关定量表型的基因。我们目前正在研究内皮脂肪酶的变化影响高密度脂蛋白胆固醇（HDLC）变化的分子机制。我们已经鉴定出内皮脂肪酶基因启动子中影响 HDLC 的功能变异。此外，我们还鉴定了与这些功能变体之一差异结合的转录因子，并量化了狒狒肝脏中转录因子的表达，证明了低 HDLC 狒狒和高 HDLC 狒狒之间的差异。