EFFECT OF LOW-CARBOHYDRATE INTAKE ON CARDIOVASCULAR RISK FACTORS AMONG OBESE ADU

低碳水化合物摄入量对肥胖成人心血管危险因素的影响

• 批准号: 7959839
• 负责人: Lydia Bazzano
• 金额: $ 26.5万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959839
• 关键词: Adult; Biology; Blood Pressure; Body Weight; Body Weight decreased; Body fat; C-reactive protein; Carbohydrates; Cardiovascular Diseases; Cause of Death; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Counseling; Data; Diastolic blood pressure; Diet; Dietitian; Fat-Restricted Diet; Fatty acid glycerol esters; Funding; Glucose; Grant; High Density Lipoprotein Cholesterol; Hypertension; Inflammatory; Institution; Insulin; Intake; Intervention; Investigation; Leptin; Life Style; Lipids; Long-Term Effects; Macronutrients Nutrition; Obesity; Participant; Plasma; Proteins; Public Health; Randomized; Randomized Controlled Trials; Recommendation; Renal Hypertension; Research; Research Personnel; Resources; Risk Factors; Serum; Source; Triglycerides; United States; United States National Institutes of Health; Upper arm; Weight maintenance regimen; adiponectin; cardiovascular disorder risk; cardiovascular risk factor; career; eligible participant; experience; meetings; novel; resistin; saturated fat; skills; waist circumference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular diseases (CVD) remain the leading cause of death globally as well as here in the United States . Manipulations of the macronutrient (protein, carbohydrate and fat) contents of diet have been used extensively for weight loss and weight control in the past several decades. Low carbohydrate diets, in particular, have gained popularity for weight loss. However, few studies have examined the effects of a diet low in carbohydrates on traditional and novel cardiovascular risk factors in the long term, particularly in contrast to the current dietary recommendations for decreased fat intake to reduce risk of CVD. In this proposal, we plan to conduct a 12-month, parallel-arm, randomized controlled trial of a diet low in carbohydrates versus the currently recommended diet low in fat diet to reduce CVD risk factors among obese adults. The objective of this trial is to examine the long-term effects of a diet low in carbohydrates, as compared to one low in fat, on CVD risk factors, including blood pressure (BP), body weight and composition, serum lipids, plasma glucose, insulin, adipocytokines (adiponectin, leptin, resistin), and C-reactive protein (CRP) among obese adults. In order to accomplish these objectives we will randomize 130 eligible participants (n=65 in each group) to consume either a diet low in carbohydrates (40 g/d) or a diet low in fat (7% saturated fat, 35% total fat). Neither of the diets will be energy-restricted. Participants will meet with a dietitian for one-on-one counseling session weekly for the first 4 weeks, then bi-weekly in small group sessions for the next 5 months, and monthly in larger group sessions for the final 6 months of the intervention. Data on both traditional and novel CVD risk factors will be collected at baseline, 3, 6, and 12 months. We hypothesize that a diet low in carbohydrates as compared to a diet low in fat will lower systolic and diastolic BP, body weight, total percent body fat, waist circumference, serum levels of triglycerides, and plasma levels of insulin, glucose, leptin, resistin, and CRP, and increase serum levels of HDL-cholesterol and adiponectin. Because CVD is the most common cause of death here in the U.S. and world-wide, this study has important public health implications. It will provide new information on the potential long-term effects of diets low in carbohydrates on both the traditional risk factors for CVD as well as novel risk factors and inflammatory factors. The results from this study will help to determine if a diet low in carbohydrates as compared to the currently recommended low fat diet can decrease the risk of CVD among obese adults. In addition, this trial will provide the junior investigator, Dr. Bazzano, an opportunity to acquire research skills and experience necessary to launch a successful, sustainable, and independent research career in the investigation dietary and lifestyle approaches to reduce risk factors for hypertension and CVD.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 心血管疾病（CVD）在全球以及美国的主要原因。在过去的几十年中，已广泛使用了饮食的大量营养素（蛋白质，碳水化合物和脂肪）的操纵。尤其是碳水化合物饮食的低碳水化合物因减肥而闻名。然而，很少有研究研究碳水化合物低的饮食对传统和新型心血管危险因素的影响，尤其是与当前的饮食建议减少脂肪摄入以降低CVD风险相比。在此提案中，我们计划对低碳水化合物的饮食进行12个月的平行臂随机对照试验，而当前推荐的脂肪饮食中的饮食饮食低，以降低肥胖成年人的CVD危险因素。该试验的目的是检查碳水化合物低的饮食对CVD危险因素的长期影响，包括血压（BP），体重和组成，血清脂质，血浆葡萄糖，胰岛素，脂肪细胞因子，脂肪细胞因子（脂肪素，脂肪素，瘦素，抗素）和蛋白质（蛋白质）（蛋白质）（蛋白质）（蛋白质）（蛋白质）（蛋白质）（蛋白质）（of）为了实现这些目标，我们将将130名合格参与者（每组n = 65个）随机，以消耗低碳水化合物（40 g/d）的饮食或低脂肪（7％饱和脂肪，总脂肪35％）的饮食。饮食都不会受到能量限制。参与者将每周与营养师举行每周一次的一对一咨询会议，然后在接下来的5个月内每两周进行小组会议，并每月在干预的最后6个月中进行较大的小组会议。传统和新型CVD风险因素的数据将在基线，3、6和12个月收集。我们假设与低脂肪的饮食相比，碳水化合物的饮食较低，脂肪的饮食将降低收缩压和舒张压，体重，体重，体重百分比，腰围，甘油三酸酯的血清水平以及血浆胰岛素，葡萄糖，葡萄糖，瘦素，瘦素，抵抗蛋白，抗素，和CRP，以及HDL-ChoLSTERLESTERSERSTERLESTERSINCIN的水平。由于CVD是美国和全球最常见的死亡原因，因此这项研究具有重要的公共卫生影响。它将提供有关低碳水化合物饮食对CVD的传统危险因素以及新型危险因素和炎症因素的潜在长期影响的新信息。 这项研究的结果将有助于确定与当前建议的低脂饮食相比，碳水化合物的饮食是否较低，可以降低肥胖成年人中CVD的风险。此外，该试验将为初级调查员Bazzano博士提供获得研究技能和经验的机会，从而在调查中开展了成功，可持续和独立的研究生涯，以减少高血压和CVD的危险因素。