MALARIAL ADENOSINE DEAMINASES

疟疾腺苷脱氨酶

• 批准号: 7955209
• 负责人: STEVEN G ALMO
• 金额: $ 0.54万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955209
• 关键词: Adenosine; Biological Factors; Coformycin; Computer Retrieval of Information on Scientific Projects Database; DNA; Enzymes; Erythrocytes; Funding; Grant; Human; Hypoxanthines; Institution; Parasites; Plasmodium; Plasmodium falciparum; Purines; RNA chemical synthesis; Research; Research Personnel; Resources; Source; United States National Institutes of Health; adenosine deaminase; analog; inhibitor/antagonist; purine; purine metabolism; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Plasmodium falciparum is a purine auxotroph, salvaging purines from erythrocytes for synthesis of RNA and DNA. Hypoxanthine is the key precursor for purine metabolism in Plasmodium. Adenosine deaminase is one of key enzymes to salvage hypoxanthine from adenosine in this parasite and the coformycin-derivates represent a promising class of potent natural-product transition state analogue inhibitors of malarial adenosine deaminase. Recognition of a methylthio-adenosine substrate by malarial, but not human, adenosine deaminase underlies selective inhibition by methylthio-coformycin.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 恶性疟原虫是一种嘌呤型菌群，从红细胞中挽救了嘌呤，用于合成RNA和DNA。低黄嘌呤是疟原虫代谢的关键前体。腺苷脱氨酶是该寄生虫中从腺苷挽救腺苷的关键酶之一，同霉素衍生物代表了一种有希望的有效的自然产物过渡状态过渡状态类似物抑制剂。通过疟疾而非人类的腺苷脱氨酶识别甲基噻吩并腺苷底物，甲基硫醇 - 甲霉素是选择性抑制的。