STRUCTURAL GENOMICS RAO

结构基因组学

• 批准号: 7957283
• 负责人: SUBRAMANYAM SWAMINATHAN
• 金额: $ 13.63万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957283
• 关键词: Amino Acid Sequence; Bioinformatics; Biological Process; Biology; Computer Retrieval of Information on Scientific Projects Database; Crystallography; DNA Microarray Chip; Family; Funding; Goals; Grant; Haemophilus influenzae; Homologous Protein; Hybrids; Institution; Light; Macromolecular Complexes; Modeling; Pathway interactions; Peptide Sequence Determination; Protein Structure Initiative; Proteins; Research; Research Personnel; Resources; Screening procedure; Set protein; Source; Structure; Synchrotrons; Techniques; United States National Institutes of Health; X-Ray Crystallography; base; member; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Biology Department of BNL is a member of the NYSGXRC funded by the National Institutes of Health under their Protein Structure Initiative (PSI) program. The goal of the PSI is to provide structural information for virtually all naturally occurring protein sequences using a combination of experimental and structure modeling techniques. The NYSGXRC uses X-ray crystallography for structure determination and MODELER for modeling homologous proteins of the same family. Many of the target selection strategies of the NYSGXRC are biologically based, providing a set of proteins that are related and representative of a larger set of proteins in some fashion. The strategies include: all members of an enzymatic pathway, each protein in macromolecular complex, interacting partners of related proteins identified using 2-hybrid screening or bioinformatics analysis, or a group of gene products up and down-regulated in a biological process as determined by DNA-microarray techniques, or a group of proteins of unknown function and structure but known to be important for the survival of H. influenzae.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 BNL生物学系是由美国国立卫生研究院蛋白质结构计划（PSI）计划（PSI）计划资助的NYSGXRC的成员。 PSI的目的是使用实验和结构建模技术的组合为几乎所有天然发生的蛋白质序列提供结构信息。 NYSGXRC使用X射线晶体学来确定结构和建模器来对同一家族的同源蛋白进行建模。 NySGXRC的许多目标选择策略都是基于生物学的，提供了一组蛋白质，这些蛋白质以某种方式相关并代表了一组较大的蛋白质。这些策略包括：酶促途径的所有成员，大分子复合物中的每种蛋白质，使用2杂交筛选或生物信息学分析鉴定的相关蛋白质的相互作用伙伴，或一组基因产物，在生物学过程中向上和下调，由由生物学过程中调节DNA微阵列技术，或一组功能和结构未知的蛋白质，但已知对于h. h. th.