STRUCTURAL GENOMICS

结构基因组学

• 批准号: 7726265
• 负责人: SUBRAMANYAM SWAMINATHAN
• 金额: $ 17.22万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-18 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7726265
• 关键词: Amino Acid Sequence; Bioinformatics; Biological Process; Biology; Computer Retrieval of Information on Scientific Projects Database; DNA Microarray Chip; DNA Microarray format; Family; Funding; Goals; Grant; Haemophilus influenzae; Homologous Protein; Hybrids; Institution; Macromolecular Complexes; Modeling; Pathway interactions; Peptide Sequence Determination; Protein Structure Initiative; Proteins; Research; Research Personnel; Resources; Screening procedure; Set protein; Source; Structure; Techniques; United States National Institutes of Health; X-Ray Crystallography; base; member; programs; structural genomics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Biology Department of BNL is a member of the NYSGXRC funded by the National Institutes of Health under their Protein Structure Initiative (PSI) program. The goal of the PSI is to provide structural information for virtually all naturally occurring protein sequences using a combination of experimental and structure modeling techniques. The NYSGXRC uses X-ray crystallography for structure determination and MODELER for modeling homologous proteins of the same family. Many of the target selection strategies of the NYSGXRC are biologically based, providing a set of proteins that are related and representative of a larger set of proteins in some fashion. The strategies include: all members of an enzymatic pathway, each protein in macromolecular complex, interacting partners of related proteins identified using 2-hybrid screening or bioinformatics analysis, or a group of gene products up and down-regulated in a biological process as determined by DNA-microarray techniques, or a group of proteins of unknown function and structure but known to be important for the survival of H. influenzae.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 BNL 生物学系是 NYSGXRC 的成员，由美国国立卫生研究院根据其蛋白质结构倡议 (PSI) 计划资助。 PSI 的目标是结合实验和结构建模技术，为几乎所有天然存在的蛋白质序列提供结构信息。 NYSGXRC 使用 X 射线晶体学进行结构测定，并使用 MODELER 对同一家族的同源蛋白质进行建模。 NYSGXRC 的许多靶标选择策略都是基于生物学的，提供一组相关的蛋白质，并以某种方式代表更大的一组蛋白质。这些策略包括：酶促途径的所有成员、大分子复合物中的每种蛋白质、使用2-杂交筛选或生物信息学分析鉴定的相关蛋白质的相互作用伙伴，或在生物过程中上调和下调的一组基因产物，如通过DNA 微阵列技术，或一组功能和结构未知但已知对流感嗜血菌生存很重要的蛋白质。