A Novel In-Vivo Cell Tracking System Based on Combined XCT and FT

基于 XCT 和 FT 组合的新型体内细胞追踪系统

• 批准号: 7327532
• 负责人: WILLIAM C BARBER
• 金额: $ 15.54万
• 依托单位: DXRAY, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7327532
• 关键词: Address; Algorithms; Animal Model; Animals; Area; Arts; Beds; California; Cardiology; Caring; Cells; Clinical; Collaborations; Compatible; Data; Deposition; Depth; Detection; Development; Disease; Dose; Dourine; Drug Delivery Systems; Ensure; Evaluation; Facility Construction Funding Category; Film; Fluorescence; Funding; Goals; Hour; Image; Imaging Device; Imaging Phantoms; Imaging technology; Invasive; Leadership; Longitudinal Studies; Magnetic Resonance Imaging; Marketing; Measurement; Medical Imaging; Methodology; Methods; Modality; Monitor; Mus; Neurology; Performance; Phase; Production; Range; Reading; Recording of previous events; Research; Research Personnel; Resolution; Scanning; Semiconductors; Signal Transduction; Site; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Source; Stem Cell Research; Stem cells; System; Systems Integration; Techniques; Technology; Testing; Therapeutic; Time; Travel; Tube; United States National Institutes of Health; Universities; X-Ray Computed Tomography; anticancer research; base; cost; design; design and construction; detector; experience; improved; in vivo; innovation; interest; molecular imaging; new technology; novel; novel strategies; oncology; pre-clinical; preclinical study; programs; prototype; reconstruction; red mercuric iodide; research study; response; scale up; technological innovation; tomography; tool; trafficking

DESCRIPTION (provided by applicant): We propose to build the world's first combined x-ray computed tomography (XCT) and fluorescence tomography (FT) system. The construction of this system will create a new molecular imaging tool for researchers performing stem cell and cancer research. Stem cell research holds great promise for the development of cellular therapies for the treatment of disease and the development of cell tracking methods is therefore extremely significant. Several important scientific and technological innovations developed by our team of investigators at DxRay Inc. (Northridge, CA) and the University of California Irvine (UCI) allow the creation of a novel combined XCT and FT system. This project produces a unique dual-modality imaging methodology that combines functional and anatomical information and provides a new approach to molecular imaging. At the completion of the proposed project the combined XCT and FT system will add unique imaging capabilities to the animal imaging facilities at UCI. Furthermore, the innovative XCT technology developed by DxRay and the novel FT technology developed by UCI will be commercialized with support from Gamma Medica Ideas (Northridge, CA) who are very interested in this development and are providing a gantry for the combined system. Cellular therapeutics show great promise for the treatment of many diseases, but unfortunately few non-invasive techniques exist for tracking the cells after administration. The ability to non-invasively monitor cell trafficking in-vivo longitudinally is a pressing need for emerging cellular therapeutic strategies since this could be used to assess response. In-vivo tracking of cells has a broad range of potential applications in various diseases covering the fields of neurology, oncology, and cardiology. Therefore, to address the need for new multi-modality molecular imaging technologies, that are capable of the non-invasive in-vivo longitudinal imaging of mice for cell tracking, we propose to build the first of its kind combined XCT and FT system. The development of this very promising new technology, the first to combine FT with anatomical information from XCT in a relatively inexpensive and easy to use system, will create a powerful new tool for stem cell research and targeted drug delivery studies. We are developing novel in-vivo combined x-ray computed tomography (XCT) and fluorescence tomography (FT) system. This new technology will create a new type of dual-modality molecular imaging. This project will create new cell tracking capabilities and will benefit preclinical studies of cellular therapies.

描述（由申请人提供）：我们建议建造世界上第一个组合的X射线计算机断层扫描（XCT）和荧光断层扫描（FT）系统。该系统的构建将为进行干细胞和癌症研究的研究人员创造一种新的分子成像工具。干细胞研究为疾病治疗的细胞疗法的发展带来了巨大的希望，因此细胞追踪方法的发展极其重要。我们的 DxRay Inc.（加利福尼亚州北岭）和加州大学欧文分校 (UCI) 的研究团队开发了几项重要的科学和技术创新，可以创建新颖的 XCT 和 FT 组合系统。该项目产生了一种独特的双模态成像方法，结合了功能和解剖信息，并提供了一种新的分子成像方法。拟议项目完成后，XCT 和 FT 组合系统将为 UCI 的动物成像设施增添独特的成像功能。此外，DxRay 开发的创新 XCT 技术和 UCI 开发的新颖 FT 技术将在 Gamma Medica Ideas（加利福尼亚州北岭）的支持下实现商业化，Gamma Medica Ideas 对此开发非常感兴趣，并为组合系统提供龙门架。细胞疗法在治疗许多疾病方面显示出巨大的前景，但不幸的是，很少有非侵入性技术可以在给药后追踪细胞。新兴细胞治疗策略迫切需要非侵入性纵向监测体内细胞运输的能力，因为这可用于评估反应。细胞体内追踪在神经病学、肿瘤学和心脏病学领域的各种疾病中具有广泛的潜在应用。因此，为了满足对新的多模态分子成像技术的需求，这些技术能够对小鼠进行非侵入性体内纵向成像以进行细胞追踪，我们建议建立第一个组合的 XCT 和 FT 系统。这项非常有前途的新技术的开发，首次将 FT 与 XCT 的解剖信息结合在一个相对便宜且易于使用的系统中，将为干细胞研究和靶向药物输送研究创造一个强大的新工具。我们正在开发新型体​​内组合 X 射线计算机断层扫描 (XCT) 和荧光断层扫描 (FT) 系统。这项新技术将创造一种新型的双模态分子成像。该项目将创造新的细胞追踪功能，并将有利于细胞疗法的临床前研究。