PEDIATRIC HIV/AIDS COHORT STUDIES: ADOLESCENT MASTER PROTOCOL (AMP)

儿科 HIV/艾滋病队列研究：青少年主方案 (AMP)

• 批准号: 7951181
• 负责人: DOUGLAS WATSON
• 金额: $ 5万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951181
• 关键词: AIDS/HIV problem; Adherence; Adolescence; Adolescent; Behavior; Birth; Bone Growth; Cardiovascular Physiology; Child; Clinical Research; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Country; Development; Evolution; Fatty acid glycerol esters; Funding; Grant; Growth and Development function; HIV; HIV Infections; Health Status; Healthcare; Hepatic; Infant; Institution; Intervention; Kidney; Knowledge; Life; Perinatal; Pharmaceutical Preparations; Play; Process; Protocols documentation; Quality of life; Research; Research Personnel; Resistance; Resources; Role; Source; Time; Treatment Failure; United States National Institutes of Health; Vertical Disease Transmission; Virus; Youth; base; cohort; design; improved; pediatric human immunodeficiency virus; prevent; transmission process; viral resistance

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The advent of potent ART has resulted in the survival into adolescence of an increasing proportion of infants and children with perinatal HIV infection. At the same time, the number of newly HIV-infected infants in the U.S. has decreased dramatically since 1993 with the development of effective means to prevent mother-to child transmission of HIV. Thus, the largest group of children with perinatal HIV infection in the U.S. consists of pre- adolescents and adolescents. Some of these children represent long-term slow-progressors, while others have benefited from potent combination ART. The impact of HIV infection and its treatment on the growth and development of this cohort of children who have been living with HIV infection since birth is not fully known. The PHACS AMP protocol is designed to study the effect of HIV infection on key processes of maturation such as pubertal development, bone growth, fat distribution, and hepatic, renal and cardiovascular functions. In addition, behavior in adolescents plays a major role in adherence to medications, treatment failure, evolution of viral resistance, and secondary transmission of HIV, including the transmission of resistant virus, to others. This knowledge can form the basis for interventions to improve the quality of life of infected children. Unfortunately, the number of HIV-infected infants, children and adolescents worldwide is growing substantially in both resource-poor countries and in countries with increasing levels of health care. Thus the information gained from this study will benefit the increasing number of infected youth worldwide.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 有效的艺术的出现导致了越来越多的婴儿和围产期HIV感染儿童比例的生存。同时，自1993年以来，随着开发有效手段以防止母亲到儿童传播艾滋病毒，美国新近感染的HIV感染的婴儿的数量已大大减少。因此，美国最大的患有围产期HIV感染的儿童由前青少年和青少年组成。这些孩子中的一些代表了长期的慢速发展，而另一些孩子则从有效的组合艺术中受益。艾滋病毒感染及其治疗对自出生以来一直患有艾滋病毒感染的儿童的生长和发展的影响尚不完全清楚。 PHACS AMP方案旨在研究HIV感染对成熟的关键过程的影响，例如青春期发育，骨骼生长，脂肪分布以及肝功能，肾脏和心血管功能。此外，青少年的行为在遵守药物，治疗衰竭，病毒抗性的进化以及HIV的二次传播中起着重要作用，包括抗性病毒的传播，向其他人传播。这些知识可以为改善感染儿童的生活质量而构成干预措施的基础。不幸的是，在资源贫乏的国家和医疗保健水平越来越高的国家中，全世界的艾滋病毒感染婴儿，儿童和青少年的数量正在大幅增长。因此，从这项研究中获得的信息将使全球受感染的青年越来越多。