EXPLORATION OF THE WEIGHT NEUTRAL EFFECTS OF INSULIN DETEMIR COMPARED TO INSULIN

与胰岛素相比，地特胰岛素的体重中性效应的探索

• 批准号: 7952083
• 负责人: MARK R BURGE
• 金额: $ 3.58万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952083
• 关键词: Affect; Calories; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Desire for food; Diabetes Mellitus; Diet Habits; Eating; Funding; Grant; Institution; Insulin; Insulin-Dependent Diabetes Mellitus; Long-Acting Insulin; New Mexico; Normal Pressure Hydrocephalus; Patients; Pilot Projects; Research; Research Personnel; Resources; Source; United States Food and Drug Administration; United States National Institutes of Health; Universities; Weight; Weight Gain; diabetic patient; glargine; insulin detemir

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is examining if and how insulin affects weight and eating habits in people with type 1 diabetes. Patients with diabetes treated with insulin often gain weight, which may deter them from adhering to insulin treatment. Detemir is one type of long acting insulin approved by the Food and Drug Administration for use in people with diabetes. It is similar to other long acting insulins [NPH, glargine] except that it has been associated with less weight gain compared to other types of insulin. The reasons for this are still unclear. One possibility is that detemir insulin acts differently than do other insulins in affecting how diabetic patients eat meals. The purpose of this study is to determine whether appetite and calories eaten during a meal are affected by the type of insulin used to treat diabetes. This is a pilot study which means we are gathering preliminary information to determine if a larger study can be done.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究正在研究胰岛素是否以及如何影响 1 型糖尿病患者的体重和饮食习惯。 使用胰岛素治疗的糖尿病患者经常体重增加，这可能会阻止他们坚持胰岛素治疗。地特胰岛素是美国食品和药物管理局批准用于糖尿病患者的一种长效胰岛素。它与其他长效胰岛素 [NPH、甘精胰岛素] 相似，但与其他类型的胰岛素相比，它与体重增加较少相关。其原因尚不清楚。一种可能性是，地特胰岛素在影响糖尿病患者饮食方面的作用与其他胰岛素不同。本研究的目的是确定用于治疗糖尿病的胰岛素类型是否会影响膳食中的食欲和卡路里摄入量。这是一项试点研究，这意味着我们正在收集初步信息，以确定是否可以进行更大规模的研究。