THE EFFECT OF ETHANOL ON OVERNIGHT GLUCOSE REGULATION IN TYPE 2 DIABETES

乙醇对 2 型糖尿病患者夜间血糖调节的影响

• 批准号: 7716583
• 负责人: MARK R BURGE
• 金额: $ 4.02万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716583
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Dose; Elderly; Ethanol; Funding; Grant; Hormones; Hypoglycemia; Hypoglycemic Agents; Institution; Insulin; Non-Insulin-Dependent Diabetes Mellitus; Patients; Physiological Processes; Placebos; Recovery; Research; Research Personnel; Resources; Sleep; Source; United States National Institutes of Health; alcohol effect; blood glucose regulation; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Moderate doses of ethanol cause overnight hypoglycemic vulnerability in elder, insulin requiring patients with type 2 diabetes by interfering with one or several of the physiologic processes critical to the defense against hypoglycemia. The alteration investigated in this study is exacerbation of the deficient counterregulatory response to hypoglycemia that occurs normally during sleep. To compare the overnight effects of moderate doses of both orally and intravenously administered ethanol or placebo on counterregulatory hormone release and recovery from insulin-induced hypoglycemia during sleep among 12 elder healthy and 12 elder subjects with insulin requiring type 2 diabetes.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 中等剂量的乙醇会干扰一种或几种对于防御低血糖至关重要的生理过程，从而导致老年人夜间出现低血糖，需要胰岛素的 2 型糖尿病患者。 本研究调查的改变是睡眠期间通常发生的低血糖反调节反应不足的加剧。 比较 12 名健康老年受试者和 12 名需要胰岛素的 2 型糖尿病老年受试者，夜间口服和静脉注射中等剂量的乙醇或安慰剂对反调节激素释放和睡眠期间胰岛素引起的低血糖恢复的影响。