Lipidomics Shared Resource

脂质组学共享资源

基本信息

批准号：
7944514
负责人：
ALICJA BIELAWSKA
金额：
$ 7.26万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-01 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7944514
关键词：
1,2-diacylglycerol Accounting Advisory Committees Antineoplastic Agents Arts Biochemistry Biocompatible Materials Biological Biological Models Biology Blood Cancer Center Cancer Center Planning Grant Cancer Center Support Grant Cell Aging Cell Death Cell Nucleus Cells Centers of Research Excellence Ceramides Chemicals Databases Development Diglycerides Drug resistance Ensure Enzymes Equipment Funding Goals Head and Neck Cancer Indium Individual Inflammation Investigation Lipids Malignant Neoplasms Mediating Medical Metabolism Methodology Molecular Molecular Biology NCI Center for Cancer Research Neoplasm Metastasis Organelles Play Program Research Project Grants Prostate Protein Analysis Publications Reagent Research Research Personnel Research Support Resource Sharing Resources Role Sampling Seminal Services Solubility South Carolina Sphingolipids Sphingosine System Techniques Tissues Translational Research Tumor Biology Universities Work analog angiogenesis cancer therapy cell growth cell motility cell transformation ceramide 1-phosphate cost design experience galactosylgalactosylglucosylceramidase improved in vivo inhibitor/antagonist insight interest lipid metabolism member new technology novel novel therapeutics programs response sphingosine kinase tool translational study tumor growth vascular inflammation water quality water solubility

项目摘要

The Hollings Cancer Center (HCC) Lipidomics Shared unique to the Medical University of South Carolina. Th and promote research into the role of bioactive lipids a metabolites, including diacylglycerol, phosphatidylinosi sphingosine, ceramide-1 -phosphate and sphingosine-1 that mediate and regulate various cell responses, inclu inflammation, cell migration and cell senescence. How challenging. Their poor water solubility makes these m accurate analysis requires sophisticated equipment, ar needed as standards for quantification and for function Shared Resource is staffed by an exceptional group of development of sensitive and accurate techniques for t well as the synthesis of bioactive lipids and novel anak provision of state-of-the-art facilities and sophisticated otherwise be prohibitively expensive. The specific objectives of the Lipidomics Shared Resoi ¿ Provide synthetic lipids, their analogs, and inhibitor sphingolipids ¿ Provide qualitative and quantitative analysis of lipid ¿ Assist HCC investigators in the design and conduc bioactive lipids, their metabolism, analysis and func ¿ Improve and develop new techniques for lipid anah the role of bioactive lipids and new potential antica composition of normal and transformed cells and o to analysis of their metabolism

Hollings癌症中心（HCC）脂质组学共享南卡罗来纳州医科大学独有。 Th 并促进对生物活性脂质作用的研究代谢物，包括二酰基甘油，磷脂酰磷酸鞘氨醇，神经酰胺-1-磷酸盐和鞘氨醇-1 介导和调节各种细胞反应，包括炎症，细胞迁移和细胞感应。如何具有挑战性的。他们的水溶性差使这些m 准确的分析需要复杂的设备，AR 需要作为数量和功能的标准共享资源由一个杰出的组成开发敏感和准确的T技术以及生物活性脂质和新颖Anak的合成提供最先进的设施和精致的否则被禁止昂贵。脂质组学的特定对象共享resoi �提供合成脂质，类似物和抑制剂鞘脂 »提供脂质的定性和定量分析 �协助HCC调查人员进行设计和行为生物活性脂质，它们的新陈代谢，分析和功能 �改进并开发脂质anah的新技术生物活性脂质和新的潜在抗原的作用正常细胞和O的组成以及O 分析其新陈代谢