Pittsburgh Center for Pain Research Recruitment of a New Faculty Member

匹兹堡疼痛研究中心招聘新教员

• 批准号: 7861169
• 负责人: Gerald F Gebhart
• 金额: $ 62.85万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7861169
• 关键词: Pittsburgh; Center; Pain; Research; Recruitment

DESCRIPTION (provided by applicant): Pain is the principal reason for seeking medical attention. Aim is not restricted to a single disease or medical discipline. Pain is, instead, distributed across the span of life, is experienced by all persons irrespective of status (economic, educational, etc.) or gender and arises from all tissues of the body. While acute episodes of pain typically resolve, many tissue insults lead to chronic pain states, and some pain syndromes are not associated with demonstrable pathology. The mechanisms that lead to tissue hypersensitivity and chronic pain, which negatively impacts quality of life, workplace productivity, interpersonal relationships, etc. at enormous cost, are poorly understood. Study of these mechanisms is the principal focus of research in the Pittsburgh Center for Pain Research (Center). Core faculty in the Center include those with a focus on transduction and signaling in nociceptors innervating superficial as well as deep tissues (e.g., muscle and viscera), circuitry and modulation of nociceptive input in the medullary and spinal dorsal horn, genetic mechanisms of individual variability in pain traits, and mechanisms that underlie sensory neuron development, differentiation and function in the adult nervous system. The Aim of the PROGRAM PLAN that is the basis of this application is to expand the breadth and depth of research expertise and research programs in the Center by recruitment through this RFA of a new junior faculty member into the Center. Core faculty has identified two broad areas of research important for growth of the Center: Translational Research, specifically epidemiology, clinical psychology, brain imaging or microneurography. Immunology or Molecular Biology We have identified areas for recruitment that will make the Center a better research and training environment and, because of our commitment to research excellence and collegiality; will enhance the research program and career development of the recruit as well. PUBLIC HEALTH RELEVANCE: Given the magnitude of personal and societal costs associated with ersistent pain states, its indiscriminate expression and the inability of the medical community to effectively manage many pain states, investing in the growth and breadth of a group of interactive, collaborative investigators in the Center - as requested in this application - addresses a fundamentally important public health issue.

描述（申请人提供）：疼痛是寻求医疗护理的主要原因。目标不仅限于单一疾病或医学学科。相反，疼痛是分散在整个生命范围内的，无论身份（经济，教育等）或性别如何，都会经历所有人，并且来自身体的所有组织。尽管疼痛的急性发作通常可以解决，但许多组织损伤会导致慢性疼痛状态，而某些疼痛综合症与可证明的病理无关。导致组织超敏反应和慢性疼痛的机制对生活质量，工作场所生产力，人际关系等产生负面影响。这些机制的研究是匹兹堡疼痛研究中心（中心）研究的主要重点。该中心的核心教师包括那些关注的伤害感受器的转导和信号传导，这些层面以及深层组织（例如肌肉和内脏），髓质和脊髓背角中的伤害感受器的电路以及对疼痛特征的遗传机制的遗传机制和机械系统的脑类差异和机械性neury syniry synire and neuron intery neuron intery neuron and neuron intery neuron and neuron s neuron and neuron s neuron s neuron s neuron s neuron中的遗传机制的调节。该申请基础的计划计划的目的是通过招募新的初级教师的RFA招募到中心，以扩大该中心的研究专业知识和研究计划的广度和深度。核心教师已经确定了对中心增长重要的两个广泛的研究领域：转化研究，特别是流行病学，临床心理学，脑成像或微功能学。免疫学或分子生物学，我们已经确定了招募领域，这些领域将使中心成为更好的研究和培训环境，并且由于我们致力于研究卓越和合作；也将增强新兵的研究计划和职业发展。 公共卫生相关性：鉴于与疼痛状态相关的个人和社会成本的幅度，其不加选择的表达以及医学界无法有效地管理许多疼痛状态，投资于该中心的一组互动，协作研究人员的成长和广度 - 根据此应用程序的要求 - 解决了基本上重要的公共健康问题。