Pittsburgh Center for Pain Research Recruitment of a New Faculty Member

匹兹堡疼痛研究中心招聘新教员

• 批准号: 7861169
• 负责人: Gerald F Gebhart
• 金额: $ 62.85万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7861169
• 关键词: Pittsburgh; Center; Pain; Research; Recruitment

DESCRIPTION (provided by applicant): Pain is the principal reason for seeking medical attention. Aim is not restricted to a single disease or medical discipline. Pain is, instead, distributed across the span of life, is experienced by all persons irrespective of status (economic, educational, etc.) or gender and arises from all tissues of the body. While acute episodes of pain typically resolve, many tissue insults lead to chronic pain states, and some pain syndromes are not associated with demonstrable pathology. The mechanisms that lead to tissue hypersensitivity and chronic pain, which negatively impacts quality of life, workplace productivity, interpersonal relationships, etc. at enormous cost, are poorly understood. Study of these mechanisms is the principal focus of research in the Pittsburgh Center for Pain Research (Center). Core faculty in the Center include those with a focus on transduction and signaling in nociceptors innervating superficial as well as deep tissues (e.g., muscle and viscera), circuitry and modulation of nociceptive input in the medullary and spinal dorsal horn, genetic mechanisms of individual variability in pain traits, and mechanisms that underlie sensory neuron development, differentiation and function in the adult nervous system. The Aim of the PROGRAM PLAN that is the basis of this application is to expand the breadth and depth of research expertise and research programs in the Center by recruitment through this RFA of a new junior faculty member into the Center. Core faculty has identified two broad areas of research important for growth of the Center: Translational Research, specifically epidemiology, clinical psychology, brain imaging or microneurography. Immunology or Molecular Biology We have identified areas for recruitment that will make the Center a better research and training environment and, because of our commitment to research excellence and collegiality; will enhance the research program and career development of the recruit as well. PUBLIC HEALTH RELEVANCE: Given the magnitude of personal and societal costs associated with ersistent pain states, its indiscriminate expression and the inability of the medical community to effectively manage many pain states, investing in the growth and breadth of a group of interactive, collaborative investigators in the Center - as requested in this application - addresses a fundamentally important public health issue.

描述（由申请人提供）：疼痛是就医的主要原因。目标不限于单一疾病或医学学科。相反，疼痛分布在整个生命周期中，无论地位（经济、教育等）或性别如何，所有人都会经历疼痛，并且疼痛源自身体的所有组织。虽然急性疼痛发作通常会消退，但许多组织损伤会导致慢性疼痛状态，并且一些疼痛综合征与明显的病理学无关。人们对导致组织过敏和慢性疼痛的机制知之甚少，这些机制对生活质量、工作效率、人际关系等造成了巨大的负面影响，并付出了巨大的代价。对这些机制的研究是匹兹堡疼痛研究中心（中心）的主要研究重点。该中心的核心教师包括那些专注于支配浅层和深层组织（例如肌肉和内脏）的伤害感受器的转导和信号传导、髓质和脊髓背角伤害感受输入的电路和调节、个体变异的遗传机制的人员成人神经系统中感觉神经元发育、分化和功能的疼痛特征和机制。作为本申请基础的项目计划的目的是通过本 RFA 招募一名新的初级教员进入中心，从而扩大中心研究专业知识和研究项目的广度和深度。核心教师确定了对中心发展至关重要的两大研究领域：转化研究，特别是流行病学、临床心理学、脑成像或显微神经造影。免疫学或分子生物学 我们已经确定了招聘领域，这将使该中心成为更好的研究和培训环境，并且由于我们致力于卓越的研究和合作；还将加强新兵的研究计划和职业发展。 公共卫生相关性：鉴于与持续性疼痛状态相关的个人和社会成本的巨大、其不加区别的表达以及医学界无法有效管理许多疼痛状态，投资于一组互动、协作研究人员的成长和广度该中心按照本申请的要求解决一个根本性的重要公共卫生问题。