Consortium for the Study of Pancreatitis: Pittsburgh Clinical Center

胰腺炎研究联盟：匹兹堡临床中心

• 批准号: 9150582
• 负责人: DAVID Clement WHITCOMB
• 金额: $ 41.05万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-28 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9150582
• 关键词: Accelerometer; Adoption; Adult; Adult Children; Affect; Area; Bioinformatics; Biological; Biological Markers; Biometry; Caring; Case Report Form; Cellular biology; Child; Childhood; Clinic; Clinical; Clinical Research; Cohort Studies; Collaborations; Communication; Communities; Complex; Consensus; DNA; Data; Data Analyses; Development; Diabetes Mellitus; Disease; Disease Management; Disease Progression; Disease model; Duct (organ) structure; Early Diagnosis; Effectiveness; Electronic Health Record; Ensure; Environmental Risk Factor; Epidemiology; Etiology; Evolution; Exclusion Criteria; Faculty; Failure; Fibrosis; Functional disorder; Future; Genetic; Genetic Risk; Germ; Goals; Health; Hereditary Disease; Image; Inflammation; Knowledge; Leadership; Malignant neoplasm of pancreas; Measures; Medical; Methods; Modeling; Monitor; Multicenter Studies; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Pain; Pancreas; Pancreatic Diseases; Pancreatic Ductal Adenocarcinoma; Pancreatic enzyme; Pancreatitis; Participant; Pathogenesis; Pathologic; Pathway interactions; Patients; Phenotype; Physicians; Physiology; Process; Recording of previous events; Recruitment Activity; Recurrence; Registries; Research; Research Subjects; Resources; Risk; Risk Assessment; Risk Factors; Sampling; Specimen; Staging; Syndrome; Testing; Therapeutic; Time; Universities; Work; acute pancreatitis; alcoholic chronic pancreatitis; authority; base; biobank; chronic pancreatitis; clinical biomarkers; clinical infrastructure; cohort; cost; cost effective; data management; design; diabetes risk; disorder prevention; disorder subtype; experience; follow-up; gene environment interaction; genetic epidemiology; illness length; improved; individual patient; innovation; male; meetings; member; new technology; patient registry; personalized medicine; predictive modeling; programs; success; theories; therapeutic target

 DESCRIPTION (provided by applicant): Pittsburgh Clinical Center (PCC) is a clinical-translational program at the University of Pittsburgh and UPMC designed to conduct studies on recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and factors that increase the risk of fibrosis, pain, and pancreatogenic diabetes (T3cDM) in children and adults, and risk of pancreatic ductal adenocarcinoma (PDAC) in adults with CP and/or DM. Multi-disciplinary teams at the University of Pittsburgh and UPMC are organized to participate in comprehensive clinical, epidemiological and biological characterization of patients with pancreatic disorders and to define the pathophysiology of RAP & CP and their sequela. Three specific aims are proposed: Aim 1. To develop integrated clinical center core processes to facilitate data and biosample management, to maximize communication and to evaluate of new technologies. Aim 2. To establish a model longitudinal research cohort of patients during evolution of definite CP. Aim 3. To generate and test a framework to analyze risk factors affecting the progression of RAP, probable CP and definite CP, and clinically useful biomarkers to monitor disease state and endpoints. Our existing and well-established, efficient and effective clinical infrastructure for patient accrual, sample processing, disease progression assessment, data management and analysis will support the program. The rich clinical volume, expert physician phenotypers in all critical areas, established leadership in epidemiology, genetics, physiology, cell biology, imaging, biostatistics and bioinformatics, and all relevant disease subtypes, plus administrative authority in clinical and research areas for both the adult and children ensure continued success. The history of strong collaborations and working relationships of the PCC faculty with many outstanding programs at other universities will also provide momentum to the national consortium.

 描述（申请提供）：匹兹堡临床中心（PCC）是匹兹堡大学和UPMC的临床翻译计划CP和/或DM成年人的导管腺癌（PDAC）。匹兹堡大学和UPMC的多学科团队由胰腺疾病患者的综合临床，流行病学和生物学特征进行组织。 定义说唱和CP及其后遗症的病理生理学。提出了三个具体目标：目标1。开发综合的临床中心核心过程，以促进数据和生物样品管理，以最大化沟通和评估新技术。目的2。在定义的CP进化过程中，建立一个患者的纵向研究队列。目标3。生成和测试一个框架以分析影响说唱，有问题的CP和确定CP以及临床上有用的生物标志物以监测疾病状态和终点的临床有用的生物标志物的危险因素。我们现有且建立了良好的，有效的，有效的临床基础设施，用于患者辅助，样本处理，疾病进展评估，数据管理和分析将支持该计划。丰富的临床量，所有关键领域的专家身体表型，在流行病学，遗传学，生理学，生理学，细胞生物学，成像，生物统计学和生物信息学方面的领导力，以及所有相关疾病亚型，以及成人和儿童的临床和研究领域的行政权威，确保继续成功。 PCC教师与其他大学的许多杰出课程的牢固合作和工作关系的历史也将为国家财团提供势头。