Mentoring translational cognitive science for stroke recovery

指导中风康复的转化认知科学

基本信息

批准号：
7771269
负责人：
A. M. Barrett
金额：
$ 13.81万
依托单位：
KESSLER FOUNDATION, INC.
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-10 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7771269
关键词：
Acute Aftercare American Anatomic Models Animal Model Animals Applications Grants Award Ballistics Behavioral Brain Brain Injuries Bromocriptine Caring Cerebrum Chronic Clinical Clinical Research Clinical Treatment Cognitive Cognitive Science Collaborations Commit Detection Disease Feedback Funding Goals Hand Handedness Hospitalization Hypokinesia Inpatients International Intervention Laboratories Laboratory Research Learning Left Manuscripts Measures Medical Medical Students Mentors Methods Midcareer Investigator Award in Patient-Oriented Research Morbidity - disease rate Motor Movement Neurorehabilitation Neurosciences Outcome Patients Perception Performance Pharmaceutical Preparations Physical Medicine Physicians Physiological Postdoctoral Fellow Primates Psychological Theory Rattus Reading Recovery Rehabilitation Outcome Rehabilitation therapy Research Research Personnel Research Project Grants Rotation Savings Science Stimulus Stratification Stroke Survivors System Techniques Testing Time Training United States National Institutes of Health Vision Vision Disorders Visual Walking Wheelchairs Work acute stroke base cost disability distraction functional disability improved next generation novel post stroke programs response role model spatial neglect stroke recovery stroke rehabilitation theories treatment response visual feedback

项目摘要

DESCRIPTION (provided by applicant): Post-stroke, functional visual problems are frequently cerebral rather than ocular. However, brain systems are not the basis of current rehabilitation. Even marginally better outcomes in estimated 230,000 US acute stroke survivors with spatial neglect could result in annual savings > $200 million. The Candidate proposed that better spatial neglect rehabilitation outcomes may result from appropriate subject stratification: performance supported by dopaminergic "aiming" systems, as well as established perceptual "where" brain networks, determined recovery in classical animal studies. With outstanding mentoring and training, under a K08 award she developed and validated a spatial neglect assessment method quantifying these recovery components. Novel K02 studies further demonstrated that "aiming" and "where" functional stratification correlated with recovery and response to clinical treatment. Continuous NIH funding since 1999 allowed her to apply the translational stratification hypothesis to neurorehabilitation research, attracting numerous clinician-researcher trainees for hands-on training. Recently, R01 funding allows her to expand her research goals, investigating translational stratification of recovery trajectory in larger groups of stroke survivors with spatial neglect. A physician cognitive neuroscientist applying psychological theory to stroke rehabilitation, she is a unique role model for medical trainees at three distinct levels. Medical students compete for research laboratory rotations, and are mentored individually in clinical research. Physiatric resident physicians are mentored in clinical research, and physiatric residents and post-doctoral fellows perform program-required research in her laboratory, resulting in trainee-authored manuscripts and presentations (5 in 2008). The K24 mechanism provides critical protected time for the Candidate to expand the theoretical basis of her clinical research, and commit appropriately to mentoring activities. The proposal activities also build her collaboration with Anne Foundas, MD. Their developing translational neuro- anatomic model, to potentially predict recovery and response to spatial neglect treatment after stroke, is expected to generate novel hypotheses for further trainee-mentor collaboration and grant applications.

描述（由申请人提供）：冲程后，功能视觉问题通常是脑而不是眼部。但是，大脑系统不是当前康复的基础。在估计有23万美国急性中风幸存者的估计有少量的结果可能会导致每年储蓄> 2亿美元。候选人提出，更好的空间忽视康复结果可能是由适当的主题分层造成的：多巴胺能“瞄准”系统支持的绩效以及确定的“脑网络”，确定了古典动物研究中的恢复。通过出色的指导和培训，根据K08奖，她开发并验证了一种量化这些恢复组件的空间忽视评估方法。新型K02研究进一步表明，“瞄准”和“其中”功能分层与恢复和对临床治疗的反应相关。自1999年以来，NIH的连续资金使她能够将转化分层假设应用于神经康复研究，吸引了许多临床医生研究员的学员进行动手培训。最近，R01资金使她能够扩大研究目标，并在空间忽视的大型中风幸存者中调查了恢复轨迹的翻译分层。她是将心理学理论应用于中风康复的医师认知神经科学家，是三个不同层次的医疗学员的独特榜样。医学生竞争研究实验室轮换，并在临床研究中单独指导。医生在临床研究中受到指导，生理居民和博士后研究员在她的实验室中进行了计划需要的研究，从而导致了受训者作者的手稿和演讲（2008年为5）。 K24机制为候选人提供了关键的保护时间，以扩大其临床研究的理论基础，并适当地致力于指导活动。提案活动还建立了她与医学博士Anne Foundas的合作。他们开发的翻译神经解剖模型有可能预测中风后的空间忽视治疗的恢复和反应，预计将产生新的假设，以实现进一步的学员协作和赠款应用。