Career Development in epigenetic control of memory maintenance

记忆维持的表观遗传控制的职业发展

• 批准号: 8033641
• 负责人: GIOVANNI BOSCO
• 金额: $ 3.35万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8033641
• 关键词: Address; Adult; Affect; Area; Basic Behavioral Science; Behavior; Behavioral; Behavioral Assay; Behavioral Genetics; Biological Assay; Chromatin; Cognitive; Courtship; Disease; Drosophila genus; Enzymes; Epigenetic Process; Fibrinogen; Genes; Genetic Transcription; Goals; Histones; Human; Late-Onset Disorder; Learning; Life Expectancy; Maintenance; Memory; Memory Loss; Methods; Modeling; Molecular; Molecular Genetics; Mushroom Bodies; Play; Population; Prevention; RNA Interference; Regulation; Research; Students; Testing; Time; Training; Transgenes; Universities; base; career development; experience; feeding; in vivo; in vivo Model; inhibitor/antagonist; insight; late disease onset; long term memory; novel; novel strategies; skills; small molecule

DESCRIPTION (provided by applicant): Cognitive and memory loss disorders affect a large part of the US population, and as life expectancy of humans continues to increase, the occurrence of late onset disorders leading to behavioral deficits and memory loss is on the rise. The molecular basis of long-term memory of learned behaviors is poorly understood, and thus any molecular genetic insights into the mechanisms of learning and memory will have broad and possibly profound implications for the prevention, treatment and reversal of memory loss in humans. We propose to test the hypothesis that epigenetic factors play critical functions in maintenance of long- term memory. By using Drosophila we will explore the possible function of epigenetic factors and will investigate models that will address the interactions among learned behaviors and epigenetic processes during maintenance of long- term memory over time. PUBLIC HEALTH RELEVANCE: Cognitive and memory loss disorders affect a large part of the US population, and as life expectancy of humans continues to increase, the occurrence of late onset disorders leading to behavioral deficits and memory loss is on the rise. We will explore the possible function of epigenetic factors and will investigate models that will address the interactions among learned behaviors and epigenetic processes during maintenance of long-term memory.

描述（由申请人提供）：认知和记忆丧失障碍影响着很大一部分美国人口，随着人类预期寿命的不断延长，导致行为缺陷和记忆丧失的迟发性疾病的发生率正在上升。人们对习得行为的长期记忆的分子基础知之甚少，因此对学习和记忆机制的任何分子遗传学见解都将对人类记忆丧失的预防、治疗和逆转产生广泛且可能深远的影响。我们建议检验表观遗传因素在维持长期记忆中发挥关键作用的假设。通过使用果蝇，我们将探索表观遗传因素的可能功能，并将研究解决长期记忆维持过程中习得行为和表观遗传过程之间相互作用的模型。 公共卫生相关性：认知和记忆丧失疾病影响着很大一部分美国人口，随着人类预期寿命的不断延长，导致行为缺陷和记忆丧失的迟发性疾病的发生率正在上升。我们将探索表观遗传因素的可能功能，并将研究解决长期记忆维持过程中习得行为和表观遗传过程之间相互作用的模型。