Trans-generational Effects of Social Learning?

社会学习的跨代效应？

• 批准号: 9149314
• 负责人: GIOVANNI BOSCO
• 金额: $ 75.25万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9149314
• 关键词: Address; Animal Behavior; Animals; Cells; Cognitive; DNA; Environment; Future Generations; Generations; Health; Individual; Inherited; Lead; Learning; Molecular Genetics; Physiological; Physiology; Process; Social Interaction; benefit sharing; experience; genetic information; learned behavior; social; social learning

 DESCRIPTION (provided by applicant): It is well accepted that cognitive experiences can have physiological consequences, and this has been shown in a variety of animal species. In social animals, groups of individuals share information about the environment and about themselves. This sharing of information is beneficial to those capable of learning from the experiences of others. Social learning can be a highly advantageous adaptive strategy since it allows individuals to anticipate changes in the environment without having direct prior experience of that change. Although it is clear that social experiences can lead to physiological changes, how long-term physiological effects of social learning persist in individuals is not understood. Interestingly, because the physiological consequences of social interactions can be long-lasting it raises the exciting possibility that socially learned behaviors could result in tras-generational effects. How or even if social experiences epigenetically reprogram germline cells in order to transmit information to subsequent generation is completely unexplored territory. This proposal seeks to elucidate molecular genetic mechanisms of how physiological changes are triggered by social learning and how these physiological changes can be inherited by future generations.

 描述（由申请人提供）：人们普遍认为认知体验会产生生理后果，这在多种动物物种中都得到了证明，群体中的个体会分享有关环境和自身的信息。信息对于那些能够从他人的经验中学习的人来说是有益的，因为它允许个人在没有直接经验的情况下预测环境的变化，尽管很明显，社会经验可以。导致生理变化，长期生理影响如何社会学习在个体中持续存在的现象尚不清楚，因为社会互动的生理后果可能是持久的，这提出了令人兴奋的可能性，即社会学习行为可能如何或即使社会经历对种系进行表观遗传重新编程。该提案旨在阐明社会学习如何触发生理变化以及这些生理变化如何被后代遗传的分子遗传机制。