Adult to Adult Living Donor Liver Transplantation Cohort Study

成人至成人活体肝移植队列研究

• 批准号: 7286296
• 负责人: abraham na shaked
• 金额: $ 20.87万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-17 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7286296
• 关键词: Acute; Address; Adult; Affect; Allografting; Biometry; Cell Cycle; Cell Death; Childhood; Clinical; Clinical Research; Clinical Research Protocols; Clinical Sciences; Cohort Studies; Commit; Control Groups; Cytokine Activation; Data; Data Analyses; Databases; Development; Disease; Donor Selection; Excision; Goals; Human Resources; Immune response; Immunosuppression; Informed Consent; Institution; Investigation; Knowledge; Kupffer Cells; Laboratories; Liver; Liver diseases; Living Donor Liver Transplantation; Living Donors; Medical; Medical center; Mental disorders; Methods; Natural regeneration; Numbers; Operative Surgical Procedures; Organ; Organ Donor; Organ Transplantation; Outcome; Pathway interactions; Patient Care; Patients; Pennsylvania; Performance; Personal Satisfaction; Physicians; Preparation; Principal Investigator; Process; Prospective Studies; Protocols documentation; Rate; Research; Research Infrastructure; Research Personnel; Research Proposals; Resources; Risk; Scientist; Staging; Steroids; Subgroup; Substance abuse problem; Techniques; Therapeutic immunosuppression; Transplant Recipients; Transplantation; United States National Institutes of Health; Universities; University Hospitals; Waiting Lists; biopsychosocial; clinical epidemiology; clinically relevant; follow-up; graft function; improved; interest; knowledge base; liver function; liver transplantation; multidisciplinary; programs; prospective; psychosocial; response; socioeconomics; success

DESCRIPTION (provided by applicant):The aim of this proposal is to demonstrate that the group of physicians and scientists at the Liver Transplant Program of the University of Pennsylvania has the interest, infrastructure and resources to participate in the Living Donor Liver Transplantation (LDLT) Cohort Study among adults awaiting transplantation. Progress in the care of patients suffering from end stage liver disease has been hampered by the limited availability of donor organs for transplantation. Adult to adult LDLT is expected to significantly expand the donor pool and provide numerous organs to be transplanted into designated recipients. The initial results are encouraging, however, there are many questions related to donor and recipient outcomes and whether better management of these patients can improve these results.A prospective mutli-center study of LDLT in the adult setting is expected to: 1. Collect and analyze data that will assist in the establishment of reliable criteria for donor selection, examine operative techniques that are associated with the best short and long term outcomes, and recommend methods for long-term follow up of the donor's physical and psychosocial well being. 2. Determine recipient outcomes when compared to the cadaveric setting and study whether results are affected by preoperative selection and preparation, operative techniques, and the interrelationship between regeneration and immune response. 3. Study the effects of LDLT on clinical practice and socioeconomic issues in transplantation. Success in addressing these problems through a national collaborative network will depend on the scientific and operational performance of the centers involved in the consortium. The Penn Transplant center is committed to participate in these collaborative efforts, and contribute to the research efforts that are aimed at better understanding of medical and surgical issues of LDLT.Our proposal is divided into three sections. Section one: A description of the resources and participation of the team of physicians at Penn Transplant Center. Section two: A description and strategy for the development of a comprehensive database. Section three: Two research proposals describing a four year research effort to identify: a. the interrelationship between the regenerative process, graft function, alloimmune response. and b. the biopsychosocial impact of LDLT on donors and recipients.

描述（由申请人提供）：该提案的目的是证明宾夕法尼亚大学肝脏移植项目的医生和科学家小组有兴趣、基础设施和资源参与活体肝脏移植（LDLT）等待移植的成年人的队列研究。由于可供移植的供体器官有限，终末期肝病患者的治疗进展受到阻碍。成人对成人的 LDLT 预计将显着扩大供体库，并提供大量器官移植到指定的受体中。初步结果令人鼓舞，但是，存在许多与捐赠者和接受者结果相关的问题，以及对这些患者的更好管理是否可以改善这些结果。成人 LDLT 的前瞻性多中心研究预计将： 1. 收集和收集分析有助于建立可靠的捐赠者选择标准的数据，检查与最佳短期和长期结果相关的手术技术，并推荐长期跟踪捐赠者身体和心理健康的方法。 2. 与尸体环境进行比较，确定受者的结果，并研究结果是否受到术前选择和准备、手术技术以及再生与免疫反应之间的相互关系的影响。 3. 研究LDLT对移植临床实践和社会经济问题的影响。通过国家协作网络成功解决这些问题将取决于参与该联盟的中心的科学和运营绩效。宾夕法尼亚大学移植中心致力于参与这些合作努力，并为旨在更好地了解 LDLT 的医学和外科问题的研究工作做出贡献。我们的提案分为三个部分。第一节：描述宾夕法尼亚州移植中心医生团队的资源和参与。第二部分：综合数据库开发的描述和策略。第三部分：两项研究提案描述了四年的研究工作，以确定：再生过程、移植物功能、同种免疫反应之间的相互关系。和b。 LDLT 对捐赠者和接受者的生物心理社会影响。