Chronic Prostatitis Collaborative Research Network

慢性前列腺炎合作研究网络

基本信息

批准号：
7404302
负责人：
RODNEY U ANDERSON
金额：
$ 12.5万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-05 至 2009-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7404302
关键词：
Algorithms Charge Chronic Disease Chronic Prostatitis Clinical Clinical Protocols Clinical Research Clinical Treatment Clinical Trials Collaborations Combined Modality Therapy Diagnostic Disease Electromyography Evaluation Exercise Functional disorder Genitourinary system Hand Interstitial Cystitis Investigation Laboratories Liquid substance Measurement Methods Modality Numbers Pain Participant Patients Pharmacologic Substance Physical Examination Physicians Population Group Principal Investigator Process Prostatic Psychophysiology Questionnaires Randomized Clinical Trials Randomized Controlled Clinical Trials Research Research Design Research Personnel Scientist Serum Markers Stretching Symptoms Testing Therapeutic Transrectal Ultrasound United States Universities Urodynamics Urology Work base chronic pelvic pain design experience medical schools member men neurobehavioral novel progressive relaxation therapy response sound trigger point

项目摘要

This application proposes that Stanford University School of Medicine, Department of Urology, participate as one of several National Clinical Centers in a cooperative effort to develop feasible clinical trials for the study of chronic prostatitis/chronic pelvic pain syndrome. The Principal Investigator intends to participate fully as a member of the steering committee in designing randomized controlled clinical trials and facilitate carrying them out in collaboration with other national center Pl's. The investigative group at Stanford will work in parallel with the centers conducting trials for investigation of interstitial cystitis. A simultaneous application for that effort is being submitted. While the precise pathophysioiogy and biologic basis of chronic pelvic pain, particularly associated with genitourinary dysfunction, have not been elucidated, a large number of men in the United States continue to suffer immeasuably for many years with this chronic disorder. Multimodal therapy exists as the only management approach and, for the most part, lacks sound scientific justification. The specific aim of this project is to utilize clinical experience from the most experienced and knowledgable physicians available to design clinical trials of treatment modalities that may provide a favorable therapeutic response among the many sub-groups of this population of patients. Investigation within these trials will stretch from pharmaceutical to complimentary holistic treatment methods, representing the best of ideas chosen by the participanting centers. The Stanford Group intends to contribute experience and expertise with regard to managing chronic prostatitis/chronic pelvic pain syndrome utilizing a neurobehavioral therapy and proposes a clinical trial of targeted physiotherapeutic myofascial release of painful trigger points with progressive relaxation exercises. The psychophysiological vagaries among patients suffering from this disorder have long been appreciated, but poorly defined, and deserve a fresh look with a dedicated "hands on" clinical effort conducted by several investigators simultaneously and with rigorous clinical research design..

本申请建议斯坦福大学医学院泌尿外科作为几个国家临床中心之一共同努力为该研究开发可行的临床试验慢性前列腺炎/慢性盆腔疼痛综合征。首席研究员打算作为主要研究者全面参与设计随机对照临床试验并促进实施的指导委员会成员他们与其他国家中心 Pl 合作。斯坦福大学的研究小组将在与开展间质性膀胱炎调查试验的中心同时进行。同时申请正在提交这项努力。虽然慢性盆腔疼痛的精确病理生理学和生物学基础，特别是与泌尿生殖功能障碍，尚未阐明，美国仍有大量男性多年来因这种慢性疾病而遭受难以估量的痛苦。多模式治疗是唯一的治疗方法管理方法，并且在很大程度上缺乏合理的科学依据。此次活动的具体目的该项目的目的是利用最有经验和知识渊博的医生的临床经验设计可能在患者中提供良好治疗反应的治疗方式的临床试验该患者群体的许多亚组。这些试验的调查将从药物到互补的整体治疗方法，代表了由医学界选择的最佳想法参与中心。斯坦福大学集团打算贡献在管理慢性病方面的经验和专业知识利用神经行为疗法治疗前列腺炎/慢性盆腔疼痛综合征，并提出了一项临床试验通过渐进式放松练习，对疼痛触发点进行有针对性的理疗肌筋膜释放。长期以来，人们一直认识到患有这种疾病的患者的心理生理变化，但定义不明确，值得通过几位专家进行的专门“实践”临床努力来重新审视研究人员同时进行严格的临床研究设计。