Reducing the Risk and Economic burden of Recurrent stroke by improving medication adherence using a Novel SMART Pill CONTAINER, Cap, and Health Literacy Technologies

使用新型智能药丸容器、瓶盖和健康素养技术提高用药依从性，降低复发性中风的风险和经济负担

• 批准号: 10601743
• 负责人: Edwin Kendrick
• 金额: $ 29.85万
• 依托单位: SANO HEALTHCARE CONSULTANTS, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601743
• 关键词: Acceleration; Adherence; Algorithms; Alloys; Archives; Area; Bar Codes; Black Populations; Black race; Calibration; Cardiovascular system; Cause of Death; Cells; Charge; Chronic; Classification; Data Scientist; Data Storage and Retrieval; Deglutition; Development; Device Designs; Devices; Disabled Persons; Disparity; Dose; Economic Burden; Engineering; Environmental Monitoring; Family; Food; Frequencies; Future; Grant; Hand; Hand functions; Health; Home; Human; Humidity; Incidence; Intervention; Ischemic Stroke; Laboratories; Language; Left; Liquid substance; Manuals; Measures; Medicine; Metals; Monitor; Morbidity - disease rate; Noise; Outcome; Periodicity; Persons; Pharmaceutical Preparations; Pharmacy Schools; Pharmacy facility; Phase; Populations at Risk; Prevention; Recurrence; Relative Risks; Research; Resolution; Risk Reduction; Rotation; Scanning; Silicones; Software Tools; Stroke; System; Target Populations; Taxonomy; Technology; Testing; Time; Universities; Upper Extremity; Water; Weight; commercialization; cost; cost effective; design; dexterity; disability; evidence based guidelines; experience; graphene; grasp; health disparity; health literacy; improved; innovation; medication compliance; medication safety; metrology; middle age; mortality; nanosheet; novel; pill; prevent; prototype; sensor; social health determinants; stroke risk; stroke survivor; touchscreen

Stroke is the leading cause of death and disability worldwide with the strongest disparity in strokes seen in Black middle-aged persons. Black persons have incidence rates of ischemic stroke that are 2- to 3-fold higher than Whites. Additionally, over 80% of stroke survivors will have immediate and persistent weakness of their upper limb, leaving half of the persons with a chronic disability and inability to complete simple and basic manual dexterity activities, including taking medications as prescribed (Medication adherence). The greatest areas where stroke survivors need help all of the time was in taking medicines out of a box, packet or bottle, with remaining support needed in managing prescriptions, receiving alerts of medication dosing times, swallowing medicines, and (d) remembering if a medication was taken. Current competitors have significant design barriers that limit access to disabled persons, medication safety, and Social Determinants of Health (SDOH). Accurate adherence monitoring requires determining whether morbidity and mortality are a result of full or partial compliance or persistent use of medication. Multiple sensors should be attached to the pill bottle to detect and monitor medication adherence to improve accuracy of detecting partial compliance, persistent use, and determining correlates of stroke-risk reduction outcomes. SANO’s novel Pharmacy Environmental Interactive Device (EID) prototype is designed to eliminate health disparities by preventing cardiovascular complications in stroke survivors by overcoming many of these barriers to medication adherence. SANO’s novel and patentable EID is designed for (a) singlehand use in stroke survivors (disability solution); (b) dual in-home dosing alert and adherence monitoring system by measuring pill weight and SMART Container manipulation (medication safety/adherence); (c) use of a cardiovascular taxonomy classification system designed for culturally sensitive and preferred health literacy language (health literacy); (d) a reusable SMART container and cap for use with low-cost cardiovascular medications (social determinants of health). SANO’s additional engineering innovation will also test two types of strain gauge sensors (metal alloy and graphene nanosheets synthesized using a water- assisted liquid phase exfoliation), thereby expanding the commercial load cell family of materials to include strain gauges as a value-based in-home prescription scale. Future health innovations and interventions must target the population at risk, the number of persons truly at risk relative to the size of the target group, be cost-effective in prevention and treatment, and be culturally sensitive to improve intervention use in the targeted population.

中风是全球死亡和残疾的主要原因，并且中风的发病率差异最大 黑人中年人中风的发病率较高。 中风的发生率是白人的 2 至 3 倍此外，超过 80% 的中风幸存者会发生中风。 上肢立即且持续无力，使一半的人患有 慢性残疾和无法完成简单和基本的手工活动， 包括按处方服用药物（药物依从性）。 中风幸存者一直需要帮助从盒子、小包或瓶子中取出药物， 在管理处方、接收药物剂量警报方面需要剩余的支持 次、吞咽药物，以及 (d) 记住当前是否服用过药物。 竞争对手有重大的设计障碍，限制了残疾人、药物的获取 安全和健康社会决定因素 (SDOH) 需要准确的依从性监测。 确定发病率和死亡率是否是完全或部分合规的结果，或 药瓶上应安装多个传感器来检测和持续使用药物。 监测药物依从性，以提高检测部分依从性、持续性的准确性 使用，并确定 SANO 新型药剂的相关性。 环境交互设备（EID）原型旨在通过以下方式消除健康差异： 通过克服其中的许多问题来预防中风幸存者的心血管并发症 SANO 的新型专利 EID 专为 (a) 中风幸存者单手使用而设计（残疾解决方案）；(b) 家庭双重用药警报和依从性。 通过测量药丸重量和智能容器操作（药物 安全性/依从性）；（c）使用专为以下目的而设计的心血管分类系统： 具有文化敏感性和首选的健康素养语言（健康素养）； (d) 可重复使用的； 智能容器和盖子，用于低成本心血管药物（社会 SANO 的额外工程创新还将测试两种类型 应变计（使用水辅助传感器合成的金属合金和石墨烯纳米片 液相剥离）从而扩展了商业称重传感器材料系列 将应变仪作为基于价值的家庭处方量表纳入未来健康创新。 干预措施必须针对面临风险的人群，真正面临风险的人数相对 根据目标群体的规模，预防和治疗具有成本效益，并具有文化特色 对改善目标人群的干预措施使用敏感。