Basic Research in Hematology and Oncology

血液学和肿瘤学基础研究

• 批准号: 7802115
• 负责人: MARC A. SHUMAN
• 金额: $ 18.96万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-05-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7802115
• 关键词: Basic Science; Hematology; oncology

DESCRIPTION (provided by applicant): This training program is designed to provide intensive laboratory training for M.D., M.D./Ph.D. as well as for Ph.D. post-doctoral fellows. The primary emphasis in the competitive renewal application will be in training physician scientists to be successful in translational biomedical laboratory research in hematology and oncology. In addition to an ongoing focus on disorders affecting the hematopoietic system, such as (1) hemoglobinopathies, and thalassemia, (2) cell biology and signal transduction and differentiation of hematopoietic cells, (3) malignancies affecting the hematopoietic and other systems, and (4) gene therapy, two new research themes, chemical biology and hematopoietic stem cells, complement these other themes. They reflect the addition of new faculty that includes Professors Carolyn Bertozzi, Michael Marletta, and James Wells, chemistry faculty, and Emmanuelle Passague in Stem Cells. In addition to training in molecular and cell biology, signal transduction, and cell differentiation, trainees will be exposed to new chemical approaches to characterizing cell surface glyosylated membrane proteins and lipids, recombinant proteins for oxygen delivery, and stem cells for the study of normal and abnormal hematopoiesis. New Training Grant faculty who will enhance the cell biology and signal transduction theme include Cynthia Kenyon who has made major discoveries in the IGF signaling pathway and in relating this pathway to aging. Our primary goal is to equip physician scientists with basic biomedical research skills that will enable them to sustain this focus after completion of training by providing opportunities in laboratories of highly successful scientists who are committed to translational research. In turn, the faculty have made a substantial commitment to training physician scientists. We will continue to recruit candidates with significant translational interest and motivation into our training program. By enrolling in an intensive laboratory research training program, trainees will extend their knowledge base and learn new research tools. We believe that the retention rate of these trainees in research will be increased significantly by the addition of the new training faculty as well as retention of many of the previous faculty.

描述（由申请人提供）： 该培训计划旨在为医学博士、医学博士/博士提供强化实验室培训。以及博士学位。博士后研究员。竞争性更新申请的主要重点是培训医师科学家，使其在血液学和肿瘤学的转化生物医学实验室研究中取得成功。除了持续关注影响造血系统的疾病，例如（1）血红蛋白病和地中海贫血，（2）细胞生物学以及造血细胞的信号转导和分化，（3）影响造血和其他系统的恶性肿瘤，以及（ 4）基因治疗，两个新的研究主题，化学生物学和造血干细胞，补充了这些其他主题。它们反映了新教师的加入，其中包括化学教师 Carolyn Bertozzi 教授、Michael Marletta 教授和 James Wells 教授以及干细胞教授 Emmanuelle Passague。除了分子和细胞生物学、信号转导和细胞分化方面的培训外，学员还将接触新的化学方法来表征细胞表面糖基化膜蛋白和脂质、用于氧输送的重组蛋白以及用于研究正常和正常细胞的干细胞。造血异常。新的培训资助教师将加强细胞生物学和信号转导主题，其中包括 Cynthia Kenyon，她在 IGF 信号通路以及该通路与衰老的关系方面取得了重大发现。 我们的主要目标是为医师科学家提供基本的生物医学研究技能，使他们能够在完成培训后继续关注这一重点，为致力于转化研究的非常成功的科学家提供实验室机会。反过来，教师们也为培养医师科学家做出了重大承诺。我们将继续招募具有浓厚翻译兴趣和动力的候选人加入我们的培训计划。通过参加强化实验室研究培训计划，学员将扩展他们的知识基础并学习新的研究工具。我们相信，通过增加新的培训教师以及保留许多以前的教师，这些受训人员的研究保留率将显着提高。