Developing School Based Treatment of ADHD Adolescents

发展多动症青少年的学校治疗

• 批准号: 7217258
• 负责人: Steven W. Evans
• 金额: $ 17.37万
• 依托单位: JAMES MADISON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7217258
• 关键词: Address; Adolescent; Age; Applications Grants; Attention deficit hyperactivity disorder; Caring; Child; Clinical Trials; Cognitive; Communities; Condition; Consultations; Controlled Clinical Trials; Data; Development; Diagnosis; Disease; Educational Intervention; Evaluation; Family psychotherapy; Goals; Guidelines; Impairment; Intervention; Literature; Manuals; Measures; Mediator of activation protein; Methods; Outcome; Outcome Measure; Participant; Performance; Pharmaceutical Preparations; Pilot Projects; Population; Procedures; Process; Psychosocial Assessment and Care; Purpose; Randomized; Randomized Clinical Trials; Range; Rate; Recreation; Recruitment Activity; Relative (related person); Reliance; Research; Research Personnel; Research Project Grants; Sample Size; Schools; Services; Site; Social Network; Staging; Students; Symptoms; Testing; Therapeutic; Training; Treatment outcome; Work; Youth; base; behavior rating scale; clinically significant; cohort; cost; design; follow-up; multilevel analysis; programs; psychosocial; response; size; skills training; social; teacher; therapy development; treatment effect; treatment program

DESCRIPTION (provided by applicant): This grant application is in response to PAR-03-078 "From Intervention Development to Services: Exploratory Research Grants (R34)." The proposed study will conduct a preliminary evaluation of a school based treatment program for middle school youth with ADHD (Challenging Horizons Program: CHP). In addition, investigators will complete the development of fidelity assessment procedures and other steps necessary according to current treatment development guidelines for the subsequent submission of a application for a full clinical trial. The CHP was initially developed in 1999 as a result of 1) the dearth of research on psychosocial treatments for ADHD in adolescents, 2) promising results in a few psychosocial treatment studies suggesting improvements in multiple domains of functioning in adolescents with ADHD, and 3) limitations associated with reliance on psychoactive medications as the only method of treatment for adolescents with ADHD. During the past five years a treatment manual and training procedures have been developed and preliminary studies have produced encouraging results. The program has been piloted at two additional sites (USC - Smith; WPIC - Molina) and their teams have contributed to the continued development and pilot testing of the procedures (see preliminary studies). Based on this work, we propose this study to complete the initial stages of the treatment development process. In addition to completing the development of fidelity assessment procedures and making final revisions to the training and treatment manuals, we will conduct a small randomized clinical trial of the CHP. A total of 44 adolescents diagnosed with ADHD will be recruited, with nearly two thirds (28) randomized to the after school program and the remaining participants (16) randomized to a community care condition. At each school two cohorts of 11 adolescents (7 treatment and 4 controls) will be treated for five months and followed for six months post treatment. Treatment will consist of academic, social, and organizational skills training, teacher consultation, family therapy, and therapeutic recreation. Primary outcome measures, including academic performance and behavior rating scales, will be collected monthly during treatment and at a 6 month follow-up point. Multilevel modeling will be used to assess group effects and treatment by medication interactions (randomization will be stratified by medication status at baseline). Furthermore, the analysis will examine rates of clinically significant change. The results of this study will provide effect size data needed to project sample size for our clinical trial as well as generate hypotheses regarding treatment moderators and mediators.

描述（由申请人提供）：本拨款申请是对 PAR-03-078“从干预开发到服务：探索性研究拨款 (R34)”的回应。拟议的研究将对患有多动症的中学生青少年的学校治疗计划（挑战视野计划：CHP）进行初步评估。此外，研究人员将根据当前治疗开发指南完成保真度评估程序和其他必要步骤的开发，以便随后提交完整临床试验的申请。 CHP 最初于 1999 年制定，原因是 1) 青少年 ADHD 心理社会治疗研究的缺乏，2) 一些心理社会治疗研究的有希望的结果表明 ADHD 青少年的多个功能领域得到改善，3)与依赖精神活性药物作为治疗青少年多动症的唯一方法相关的局限性。在过去五年中，已经制定了治疗手册和培训程序，初步研究也取得了令人鼓舞的结果。该计划已在另外两个地点（南加州大学 - 史密斯；WPIC - 莫利纳）进行了试点，他们的团队为程序的持续开发和试点测试做出了贡献（参见初步研究）。基于这项工作，我们提出这项研究来完成治疗开发过程的初始阶段。除了完成保真度评估程序的制定并对培训和治疗手册进行最终修订外，我们还将对CHP进行小型随机临床试验。总共 44 名被诊断患有 ADHD 的青少年将被招募，其中近三分之二 (28) 被随机分配到课后计划，其余参与者 (16) 被随机分配到社区护理条件。每所学校将分为两组，每组 11 名青少年（7 名治疗组和 4 名对照组）将接受为期 5 个月的治疗，并在治疗后随访 6 个月。治疗包括学术、社交和组织技能培训、教师咨询、家庭治疗和治疗性娱乐。主要结果指标，包括学业成绩和行为评分量表，将在治疗期间和 6 个月的随访点每月收集一次。多级模型将用于评估药物相互作用的群体效应和治疗（随机化将根据基线的药物状态进行分层）。此外，该分析还将检查临床显着变化的比率。这项研究的结果将提供为我们的临床试验预测样本量所需的效应量数据，并生成有关治疗调节因子和调节因子的假设。

项目成果

Effectiveness of the Challenging Horizons After-School Program for young adolescents with ADHD.

挑战视野课后计划对患有多动症的青少年的有效性。

• 发表时间: 2011-09
• 影响因子: 3.7
• 作者: Evans, Steven W;Schultz, Brandon K;Demars, Christine E;Davis, Heather
• 通讯作者: Davis, Heather