Race/Ethnicity, Psychosocial and Environmental Stressors, and Telomere Length

种族/民族、心理和环境压力因素以及端粒长度

• 批准号: 7874465
• 负责人: Arline T Geronimus
• 金额: $ 37.98万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7874465
• 关键词: Adult; Affect; Age; Aging; Area; Arts; Biochemistry; Biochemistry and Cellular Biology; Biological; Biological Aging; Biological Process; Blood; Cardiovascular system; Cell Aging; Cellular biology; Characteristics; Chronic; Chronic Disease; Cohort Effect; Collaborations; Collection; Communities; Community Health; Data; Data Set; Deterioration; Development; Differential Mortality; Disadvantaged; Disease; Disease Outcome; Economics; Ensure; Environment; Estradiol; Ethnic Origin; Ethnic group; Ethnography; Exposure to; F2-Isoprostanes; Face; Follow-Up Studies; Gender; Health; Health Services; Health Surveys; Healthcare; Historical Survey; Hormones; Inequality; Inflammation; Knowledge; Learning; Length; Leukocytes; Life; Life Expectancy; Light; Link; Measurement; Measures; Mediating; Mediator of activation protein; Metabolic; Methods; Michigan; Modeling; Molecular; Molecular Biology; Morbidity - disease rate; Neighborhoods; Nerve; Onset of illness; Oxidative Stress; Pathway interactions; Pattern; Physiology; Population; Population Study; Process; Psychology; Public Health; Race; Research; Research Personnel; Risk; Sampling; Schedule; Scientist; Series; Social Sciences; Socioeconomic Status; Staging; Stress; Surveys; Telomerase; Telomere Shortening; Testing; Universities; Venous; Vitamin E; Weather; Woman; Work; age effect; aging population; allostatic load; base; behavioral/social science; biological adaptation to stress; body system; coping; cost; environmental stressor; experience; health disparity; health inequalities; hypothalamic pituitary axis; illness length; improved; insight; interdisciplinary collaboration; interest; middle age; mortality; psychosocial; public health relevance; racial and ethnic; racial difference; response; social; socioeconomics; sound; stressor; telomere; theories; urban poverty area; young adult

DESCRIPTION (provided by applicant): We propose to conduct the first community-based study of racial differences in telomere length and allostatic load in adults of broad age range and their association with urban stressors. We hypothesize that chronic stressors experienced by black urban residents accelerate biological aging and chronic disease onset. Evidence suggests that leukocyte telomere length (TL) may be an indicator of biological age that can be affected by stress; and that allostatic load is an indicator of stress-mediated wear on important body systems. We have a unique opportunity to supplement survey data scheduled to be collected by the Healthy Environments Partnership (HEP) a partnership between the University of Michigan and community-based organizations and health service agencies in Detroit with blood collection and lab analyses of telomere length, telomere-related compounds, and allostatic load, including measures of the biological stress response, inflammation, and cardiovascular and metabolic risk. By appending a venous blood draw to the HEP survey, we can construct a data set including these biomeasures and detailed psychosocial and physical environmental measures in a cost-effective way; enhance access to a hard-to-reach population; and facilitate dissemination of study results to improve community health. We will estimate a series of regressions of TL and allostatic load on race, controlling for the confounding effects of age, gender, and socioeconomic characteristics and exploring the extent to which psychosocial or environmental stressors mediate remaining racial differences. To ensure findings are not driven by functional form we will reanalyze the data using matching methods. We will also model disease outcomes, conditional on telomere length, on high oxidative stress or low telomerase activity to explore biological mechanistic pathways between telomere length and chronic disease. Our investigative team brings exceptional expertise in social and behavioral science, cell biology, psychology and biochemistry to insure state-of-the art telomere measurement, theory-driven and statistically sound social science measures and models, and appropriate interpretation of study findings to provide important insights. We expect study findings to shed light on the plausibility of cumulative stress hypotheses to explain the social patterning of disease; the viability of telomere length as a biomeasure of aging; and the mechanistic pathways through which stressors may be linked to telomere length and disease processes. If findings from this interdisciplinary collaborative effort support study hypotheses, this could constitute a significant advance in the understanding of the biological mechanisms that underlie racial inequality in health. PUBLIC HEALTH RELEVANCE: Learning how social factors work through biological mechanisms to impact health is fundamental to understanding racial health disparities. By studying personal and neighborhood stressors and the health of Detroit residents in an interdisciplinary collaboration, we hope to shed light on this question.

描述（由申请人提供）：我们建议开展首次基于社区的研究，研究不同年龄段成年人端粒长度和稳态负荷的种族差异及其与城市压力源的关系。我们假设黑人城市居民经历的慢性压力会加速生物衰老和慢性疾病的发作。有证据表明，白细胞端粒长度（TL）可能是受压力影响的生物年龄的指标；稳态负荷是重要身体系统压力介导磨损的指标。我们有一个独特的机会来补充计划由健康环境合作组织 (HEP) 收集的调查数据，该组织是密歇根大学与底特律的社区组织和卫生服务机构之间的合作伙伴关系，通过血液采集和端粒长度、端粒的实验室分析来补充相关化合物和稳态负荷，包括生物应激反应、炎症以及心血管和代谢风险的测量。通过在 HEP 调查中附加静脉抽血，我们可以以经济有效的方式构建一个数据集，包括这些生物测量值以及详细的社会心理和物理环境测量值；增加接触难以接触人群的机会；促进研究结果的传播，以改善社区健康。我们将估计 TL 和种族调节负荷的一系列回归，控制年龄、性别和社会经济特征的混杂影响，并探索社会心理或环境压力因素在多大程度上调节剩余的种族差异。为了确保发现不是由功能形式驱动的，我们将使用匹配方法重新分析数据。我们还将根据端粒长度、高氧化应激或低端粒酶活性对疾病结果进行建模，以探索端粒长度与慢性疾病之间的生物机制途径。我们的研究团队拥有社会和行为科学、细胞生物学、心理学和生物化学方面的卓越专业知识，以确保最先进的端粒测量、理论驱动和统计上合理的社会科学测量和模型，以及对研究结果的适当解释，以提供重要的信息。见解。我们期望研究结果能够揭示累积压力假说的合理性，以解释疾病的社会模式；端粒长度作为衰老生物测量指标的可行性；以及压力源可能与端粒长度和疾病过程相关的机制途径。如果这项跨学科合作的结果支持研究假设，这可能会在理解健康种族不平等的生物机制方面取得重大进展。公共卫生相关性：了解社会因素如何通过生物机制影响健康对于理解种族健康差异至关重要。通过跨学科合作研究个人和社区压力源以及底特律居民的健康，我们希望阐明这个问题。