Development of a New Sparker Electrode for Improved Electrohydraulic Lithotripsy

开发新型火花电极以改进电液碎石术

• 批准号: 7873406
• 负责人: RAYMOND B SCHAEFER
• 金额: $ 1.03万
• 依托单位: PHOENIX SCIENCE AND TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7873406
• 关键词: Acoustics; Address; Adverse effects; CHRM3 gene; Calculi; Clinical; Collaborations; Development; Electrodes; Electromagnetics; Exhibits; Goals; Gold; Head; Kidney Calculi; Legal patent; Length; Life; Lithotripsy; Maintenance; Maps; Marketing; Measurement; Measures; Mechanics; Names; Outcome; Output; Pain; Patients; Performance; Phase; Procedures; Reporting; Reproducibility; Research; Research Personnel; Robin bird; Schedule; Shock; Source; Spatial Distribution; System; Testing; Time; Translating; Work; base; commercialization; cost; design; feeding; improved; meetings; pressure; professor; programs; prototype

DESCRIPTION (provided by applicant): Shock wave lithotripsy (SWL) is a non-invasive treatment for kidney stones and other ailments. However, current lithotripters produce painful side effects, and the mechanisms of lithotripsy and the causes of the side effects are not fully understood. Electrohydraulic lithotripters (EHL's), which use an underwater spark as a shock wave source, had been the treatment of choice but use has declined because the shocks are inconsistent, cause painful side effects and the electrodes are short lived. Typically, the electrode head wears out during a procedure, and must be replaced before completing the procedure. New types of lithotripters are more consistent and last longer than one procedure, but their clinical outcomes are reduced and side effects are greater. Phase I showed the feasibility of using a wire-initiated sparker to produce consistent and precise shocks, of controlling the shock (for potential improved comminution of kidney stones and reduction in side effects), of lasting for many procedures. The proposed Phase II continues research towards the long-term goal to develop a new commercial EHL that exceeds the clinical outcomes of lithotripters, with reduced side effects, much longer life and lower cost. The specific project objectives are to develop a wire feed system needed to employ wire- initiated sparkers for EHL, demonstrate ultra-long lifetime using the wire-feed, map out the acoustic field of the shock and cavitation in the focal region, conduct research using the sparker's varied shock waveforms to improve comminution of kidney stones and develop a prototype wire-feed sparker for commercialization. A successful project will result in improved clinical results of SWL at reduced cost. Shock wave lithotripsy (SWL) is a non-invasive treatment for kidney stones and other ailments. The electrodes in current systems must be replaced during a procedure, and the results are inconsistent, with unpleasant side effects. A successful program will result in a new SWL system with electrodes lasting several procedures, more consistent clinical outcomes, reduced side effects and lower cost.

描述（由申请人提供）：冲击波碎石术（SWL）是一种针对肾结石和其他疾病的非侵入性治疗方法。然而，目前的碎石机会产生痛苦的副作用，并且碎石机的机制和副作用的原因尚不完全清楚。电动液压碎石机（EHL）使用水下火花作为冲击波源，一直是首选的治疗方法，但由于冲击不一致、会引起痛苦的副作用且电极寿命短，其使用量已经下降。通常，电极头在手术过程中会磨损，并且必须在完成手术之前更换。新型碎石机比一种手术更一致且持续时间更长，但其临床结果降低且副作用更大。第一阶段展示了使用电线引发的火花器产生一致且精确的电击、控制电击（可能改善肾结石粉碎并减少副作用）以及持续许多手术的可行性。拟议的第二阶段继续研究，以实现长期目标，即开发一种新的商业 EHL，该 EHL 超越碎石机的临床结果，并减少副作用、延长寿命和降低成本。具体项目目标是开发一种用于 EHL 的焊丝引发火花器所需的送丝系统，使用送丝演示超长使用寿命，绘制焦点区域中冲击和空化的声场，使用火花机的各种冲击波形可改善肾结石的粉碎，并开发出用于商业化的送丝火花机原型。一个成功的项目将以更低的成本改善 SWL 的临床结果。冲击波碎石术 (SWL) 是一种治疗肾结石和其他疾病的非侵入性治疗方法。当前系统中的电极必须在手术过程中更换，并且结果不一致，并且具有令人不快的副作用。一个成功的项目将带来一个新的 SWL 系统，其电极可持续多次手术、更一致的临床结果、更少的副作用和更低的成本。