Sparker Array for Improved Electro-Hydraulic Lithotripsy (EHL)

用于改进电液碎石 (EHL) 的火花阵列

• 批准号: 7996791
• 负责人: RAYMOND B SCHAEFER
• 金额: $ 9.82万
• 依托单位: PHOENIX SCIENCE AND TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7996791
• 关键词: Adverse effects; CHRM3 gene; Calculi; Clinical; Collaborations; Coupling; Electrodes; Goals; Gold; Kidney Calculi; Lead; Life; Liquid substance; Lithotripsy; Location; Monitor; Names; Outcome; Patients; Performance; Phase; Procedures; Pulse Pressure; Research; Research Personnel; Robin bird; Shock; Source; Surface; Technology; Time; Tissues; Ultrasonography; clinical application; flexibility; improved; innovation; meetings; pressure; professor; prototype; public health relevance; success

DESCRIPTION (provided by applicant): Shock wave lithotripsy (SWL) is the first line treatment for the majority of patients with kidney stones. The gold standard in SWL is still considered to be the Dornier HM3, which was the first lithotripter introduced into the US. The HM3 is an electrohydraulic lithotripter (EHL) that uses a single underwater "sparker" as a shock wave source. The HM3 has the drawback that the electrodes erode quickly and must be replaced in the middle of a procedure, and causes significant side effects. This project is to demonstrate that an array of several sparkers in small ellipsoidal reflectors can break stones without having to stop a procedure. The relatively low electrical current in each sparker in the array reduces the erosion, which may allow the sparker array to operate for multiple treatments. The flexibility in placement of the sparkers allows space for an in-line ultrasound probe to monitor stone location during treatment, which will result in fewer pressure pulses missing the stone and reduce damage to surrounding tissue. The specific project objectives are to develop a sparker array and demonstrate its efficacy by breaking artificial stones without having to replace electrodes. A successful Phase I will lead to a Phase II to develop a prototype and demonstrate the potential for improved clinical outcomes. PUBLIC HEALTH RELEVANCE: This research can lead to improved treatment of kidney stones. A successful new lithotripter will have both a higher percentage of successes (reducing the number of repeat procedures) and less side effects to the patient.

描述（由申请人提供）：冲击波碎石术（SWL）是大多数肾结石患者的一线治疗方法。 SWL 的黄金标准仍然被认为是 Dornier HM3，它是美国引进的第一台碎石机。 HM3 是一种电动液压碎石机 (EHL)，使用单个水下“火花器”作为冲击波源。 HM3 的缺点是电极很快就会腐蚀，必须在手术过程中更换，并会造成严重的副作用。 该项目旨在证明小型椭圆形反射器中的多个火花器阵列可以在无需停止程序的情况下破碎石头。阵列中每个火花器中相对较低的电流减少了腐蚀，这可以允许火花器阵列进行多次处理。火花塞放置的灵活性为在线超声波探头提供了空间，以在治疗期间监测结石位置，这将导致错过结石的压力脉冲减少，并减少对周围组织的损伤。 具体项目目标是开发一种火花阵列，并通过在不更换电极的情况下破碎人造石来证明其功效。第一阶段的成功将导致第二阶段开发原型并展示改善临床结果的潜力。 公众健康相关性：这项研究可以改善肾结石的治疗。成功的新型碎石机将具有更高的成功率（减少重复手术的次数），并且对患者的副作用更少。